Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis.

Levantini E; Giorgetti A; Cerisoli F; Traggiai E; Guidi A; Martin R; Acampora D; Aplan PD; Keller G; Simeone A; Iscove NN; Hoang T; Magli MC

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis.

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Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis.

机译：脑形态发生基因Otx1在造血中的作用毋庸置疑。

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摘要

Otx1 belongs to the paired class of homeobox genes and plays a pivotal role in brain development. Here, we show that Otx1 is expressed in hematopoietic pluripotent and erythroid progenitor cells. Moreover, bone marrow cells from mice lacking Otx1 exhibit a cell-autonomous impairment of the erythroid compartment. In agreement with these results, molecular analysis revealed decreased levels of erythroid genes that include the SCL and GATA-1 transcription factors. Accordingly, a gain of function of SCL rescues the erythroid deficiency in Otx1-/- mice. Taken together, our findings indicate a function for Otx1 in the regulation of blood cell production.

机译：Otx1属于同源异型盒基因的配对类，并且在大脑发育中起关键作用。在这里，我们显示Otx1在造血多能性和红系祖细胞中表达。此外，来自缺乏Otx1的小鼠的骨髓细胞表现出对红系区隔的细胞自主损伤。与这些结果一致，分子分析显示包括SCL和GATA-1转录因子的类红细胞基因水平降低。因此，SCL功能的获得可以挽救Otx1-/-小鼠的红系缺乏症。综上所述，我们的发现表明Otx1在调节血细胞产生中具有功能。

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2003年第18期|P.10299-10303|共5页
作者
Levantini E; Giorgetti A; Cerisoli F; Traggiai E; Guidi A; Martin R; Acampora D; Aplan PD; Keller G; Simeone A; Iscove NN; Hoang T; Magli MC;
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作者单位

Institute of Biomedical Technologies, Consiglio Nazionale delle Ricerche, 56124 Pisa, Italy.;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
Hematopoiesis; Homeodomain Proteins; Transcription Factors; 血细胞生成; 同源域蛋白质类; 转录因子;

机译：Hematopoiesis;Homeodomain Proteins;Transcription Factors;血细胞生成;同源域蛋白质类;转录因子;

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1. Differentiation of human embryonic stem cells in serum-free medium reveals distinct roles for bone morphogenetic protein 4, vascular endothelial growth factor, stem cell factor, and fibroblast growth factor 2 in hematopoiesis. [J] . Pick M, Azzola L, Mossman A, Stem Cells . 2007,第9期

机译：人类胚胎干细胞在无血清培养基中的分化揭示了造血过程中骨形态发生蛋白4，血管内皮生长因子，干细胞因子和成纤维细胞生长因子2的独特作用。
2. The TINS Lecture. Understanding the roles of Otx1 and Otx2 in the control of brain morphogenesis. [J] . Acampora D, Simeone A Trends in Neurosciences . 1999,第3期

机译：TINS讲座。了解Otx1和Otx2在控制脑形态发生中的作用。
3. Murine Otx1 and Drosophila otd genes share conserved genetic functions required in invertebrate and vertebrate brain development. [J] . Acampora D, Avantaggiato V, Tuorto F, Development . 1998,第9期

机译：鼠Otx1和果蝇otd基因共享无脊椎动物和脊椎动物大脑发育所需的保守遗传功能。
4. Bridging the Mind-Brain Gap by Morphogenetic "Neuron Flocking": The Dynamic Self-Organization of Neural Activity into Mental Shapes [C] . Rene Doursat AAAI Fall Symposium on How Should Intelligence Be Abstracted in AI Research . 2013

机译：通过形态发生的“神经元植绒”弥合脑力脑差异：神经活动的动态自我组织成精神形状
5. The role of E2A in hematopoietic development: Establishment of a multipotent progenitor cell line to identify genetic and epigenetic regulatory programs in hematopoiesis. [D] . Mercer, Elinore McClelland. 2010

机译：E2A在造血发育中的作用：建立多能祖细胞系以鉴定造血过程中的遗传和表观遗传调控程序。
6. Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis [O] . Elena Levantini, Alessandra Giorgetti, Francesco Cerisoli, 2003

机译：脑形态发生基因Otx1的意外作用在造血作用
7. Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis [O] . Levantini, Elena, Giorgetti, Alessandra, Cerisoli, Francesco, 2003

机译：脑形态发生基因Otx1的意外作用在造血作用

Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis.

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