...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies
【24h】

Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies

机译：表达病毒中和抗体的免疫球蛋白重链的基因靶向小鼠的抗病毒免疫应答

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Two gene-targeted immunoglobulin heavy chain transgenic mouse strains, TgH(KL25) and TgH(VI10), expressing neutralizing specificities for lymphocytic choriomeningitis virus and vesicular stomatitis virus, respectively, have been generated. Three days after lymphocytic choriomeningitis virus infection, TgH(KL25) mice showed a thymus-independent neutralizing IgM response followed by thymus-depen-dent (TD) IgG. In contrast, WT mice mounted only a TD IgG response around day 80. These observations indicated that not only structural properties of the virus but also immunological parameters such as the frequency of B cells were indicative for the induction of thymus-independent versus TD Ig responses. Naive vesicular stomatitis virus-specific Ig heavy chain transgenic mice displayed greatly elevated natural antibody titers. However, despite these high naieve titers, de novo activation of naieve CD4~+ T and B cells was not blocked. Therefore, B cells giving rise to natural antibodies do not participate in virus-induced antibody responses.
机译：已经产生了两种针对基因的免疫球蛋白重链转基因小鼠品系，TgH（KL25）和TgH（VI10），分别表达对淋巴细胞性脉络膜脑膜炎病毒和水泡性口腔炎病毒的中和特异性。淋巴细胞性脉络膜脑膜炎病毒感染三天后，TgH（KL25）小鼠显示出独立于胸腺的中和IgM反应，然后出现胸腺依赖（TD）IgG。相比之下，野生型小鼠仅在第80天出现了TD IgG应答。这些观察结果表明，不仅病毒的结构特性，而且免疫参数（例如B细胞的频率）也都指示了胸腺非依赖性应答与TD Ig应答的诱导。 。幼稚水泡性口腔炎病毒特异性Ig重链转基因小鼠表现出大大提高的天然抗体滴度。然而，尽管这些天真的滴度很高，但未阻断天真的CD4〜+ T和B细胞的从头激活。因此，产生天然抗体的B细胞不参与病毒诱导的抗体应答。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号