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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses
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Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses

机译：腺苷控制海马苔藓纤维突触的突触可塑性

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摘要

The release properties of synapses in the central nervous system vary greatly, not only across anatomically distinct types of synapses but also among the same class of synapse. This variation manifests itself in large part by differences in the probability of transmitter release, which affects such activity-dependent presyn-aptic forms of plasticity as paired-pulse facilitation and frequency facilitation. This heterogeneity in presynaptic function reflects differences in the intrinsic properties of the synaptic terminal and the activation of presynaptic neurotransmitter receptors. Here we show that the unique presynaptic properties of the hippocampal mossy fiber synapse are largely imparted onto the synapse by the continuous local action of extracellular adenosine at presynaptic A1 adenosine receptors, which maintains a low basal probability of transmitter release.
机译：突触在中枢神经系统中的释放特性变化很大，不仅在解剖学上不同的突触类型之间，而且在同一类突触之间。这种变化在很大程度上通过信号发射器释放概率的差异来体现，这影响了与活动相关的突触前突触形式的可塑性，如成对脉冲促进和频率促进。突触前功能的这种异质性反映了突触末端固有特性和突触前神经递质受体激活的差异。在这里，我们显示海马生苔藓纤维突触的独特的突触前特性主要通过胞外腺苷在突触前A1腺苷受体的连续局部作用而赋予突触，这维持了低的发射机释放基础概率。

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