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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Neuroectodermal differentiation from mouse multipotent adult progenitor cells
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Neuroectodermal differentiation from mouse multipotent adult progenitor cells

机译：小鼠多能成年祖细胞的神经外胚层分化

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摘要

We recently showed that a rare cell from murine bone marrow, which we termed multipotent adult progenitor cells (MAPCs), can be expanded for >120 population doublings. Mouse (m)MAPCs differentiate into mesenchymal lineage cells as well as endothe-lium and endoderm, and, when injected in the blastocyst, mMAPCs contribute to most if not all somatic cell lineages including the different cell types of the brain. Our results, reported herein, demonstrate that mMAPCs can also be induced to differentiate into cells having anatomical and electrophysiological characteristics similar to those of midbrain neurons. Differentiation to a neuronal phenotype was achieved by coculturing mMAPCs with astrocytes, suggesting that neuronal differentiation may require astrocyte-derived factors similar to what is required for the differentiation of embryonic stem cells and neural stem cells to neurons. Differentiation of mMAPCs to neuron-like cells follows similar developmental steps as described for embryonic stem cells and neural stem cells. MAPCs therefore may constitute a source of cells for treatment of central nervous system disorders.
机译：我们最近显示，来自鼠类骨髓的稀有细胞（我们称为多能成年祖细胞（MAPC））可以扩展为> 120的人口倍增。小鼠（m）MAPC分化为间充质谱系细胞以及内皮细胞和内胚层，当注入胚泡中时，mMAPC会影响大多数（如果不是全部）体细胞谱系，包括大脑的不同细胞类型。本文报道的我们的结果证明，mMAPCs也可以被诱导分化为具有类似于中脑神经元的解剖和电生理特征的细胞。通过将mMAPC与星形胶质细胞共培养可以实现向神经元表型的分化，这表明神经元分化可能需要星形胶质细胞衍生的因子，类似于胚胎干细胞和神经干细胞分化为神经元所需的因子。 mMAPCs向神经元样细胞的分化遵循与胚胎干细胞和神经干细胞相同的发育步骤。因此，MAPC可能构成用于治疗中枢神经系统疾病的细胞来源。

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