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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Siderophore-mediated signaling regulates virulence factor production in Pseudomonas aeruginosa
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Siderophore-mediated signaling regulates virulence factor production in Pseudomonas aeruginosa

机译：铁载体介导的信号调节铜绿假单胞菌的毒力因子生产。

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摘要

Numerous bacteria secrete low molecular weight compounds termed siderophores that have a high affinity for iron ions. Sid-erophores have a well-documented role as iron-scavenging chemicals, chelating iron ions in the environment whereupon the fer-risiderophores reenter the bacterial cells by means of specific cell-surface receptors. The iron is then released for incorporation into bacterial proteins. Here we show that in addition to its role as an iron-scavenger, the siderophore pyoverdine that is secreted by Pseudomonas aeruginosa regulates the production of at least three virulence factors (exotoxin A, an endoprotease, and pyoverdine itself), which are major contributors to the ability of this bacterium to cause disease. Regulation occurs through a transmembrane signaling system that includes an outer membrane receptor for ferripyoverdine, a signal-transducing protein that is predicted to extend from the periplasm into the cytoplasm, and a sigma factor. Expression of genes that form part of the regulon is triggered by pyoverdine so that this siderophore acts as a signaling molecule to control the production of secreted products. Recognition that a siderophore acts as a signaling molecule has important implications for the understanding of interactions between bacterial cells.
机译：许多细菌分泌称为铁载体的低分子量化合物，这些化合物对铁离子具有高亲和力。 Sid-erophors作为铁清除剂具有很好的记录作用，在环境中螯合铁离子，因此fer-risiderophores通过特定的细胞表面受体重新进入细菌细胞。然后释放铁以掺入细菌蛋白中。在这里，我们显示除铜绿假单胞菌所分泌的铁载体吡d定之外，它还具有铁清除剂的作用，它调节至少三种毒力因子（外毒素A，内切蛋白酶和吡py定本身）的产生，这是造成这种情况的主要因素。这种细菌引起疾病的能力。调节是通过跨膜信号系统进行的，该系统包括一个用于ferripyoverdine的外膜受体，一个预计从周质延伸到细胞质的信号转导蛋白以及一个sigma因子。构成吡咯乙酮的基因的表达是由嘧啶定触发的，因此该铁载体起信号分子的作用来控制分泌产物的产生。铁载体起信号分子的作用对于理解细菌细胞之间的相互作用具有重要意义。

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