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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Positive selection of self-MHC-reactive T cells by individual peptide-MHC class II complexes
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Positive selection of self-MHC-reactive T cells by individual peptide-MHC class II complexes

机译：单个MHC II类肽复合物对MHC反应性T细胞的阳性选择

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摘要

If T cells require specific interactions with MHC-bound peptides during positive selection, then the specificities of T cells selected by one peptide should be distinct from those selected by another. We have examined positive selection of CD4 T cells in four strains of mice, each overexpressing a different peptide-1-A~b(A~b) complex. We show that a subset of CD4 T cells is selected by the overex-pressed peptide and that the specificities of the CD4 T cells, as measured by reactivity to wild-type antigen-presenting cells, vary greatly depending on which peptide is overexpressed. These differences in specificity are mediated through positive selection not negative selection. Each of the four peptide-A~b complexes appears to adopt a different conformation, and these differences correlate with the differences in reactivity. Our results suggest that individual peptide-MHC complexes positively select different subsets of self-MHC-reactive T cells and that the conformation of the peptide-MHC complex may contribute to this process.
机译：如果在阳性选择过程中T细胞需要与结合MHC的肽发生特异性相互作用，则一种肽选择的T细胞的特异性应不同于另一种肽选择的T细胞的特异性。我们已经检查了四种小鼠中CD4 T细胞的阳性选择，每种小鼠过表达一种不同的肽-1-A〜b（A〜b）复合物。我们显示，CD4 T细胞的一个子集由过表达的肽选择，并且CD4 T细胞的特异性（通过与野生型抗原呈递细胞的反应性来衡量）取决于哪个肽过表达而有很大差异。这些特异性差异是通过正选择而非负选择介导的。四种肽-A〜b复合物中的每一种似乎都采用不同的构象，并且这些差异与反应性的差异相关。我们的结果表明，单个肽-MHC复合物可以积极选择自身MHC反应性T细胞的不同子集，并且肽-MHC复合物的构象可能有助于这一过程。

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