Neonatal hepatic steatosis by disruption of the adenosine kinase gene

Detlev Boison; Louis Scheurer; Valerie Zumsteg

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Neonatal hepatic steatosis by disruption of the adenosine kinase gene

机译：腺苷激酶基因的破坏导致新生儿肝脂肪变性

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Neonatal hepatic steatosis (OMIM 228100) is a fatal condition of unknown etiology characterized by a pale and yellow liver and early postnatal mortality. In the present study, a deficit in adenosine-dependent metabolism is proposed as a causative fac- tor. Physiologically, adenosine is efficiently metabolized to AMP by adenosine kinase (ADK), an enzyme highly expressed in liver. ADK not only ensures normal adenine nucleotide levels but also is essential for maintaining S-adenosylmethionine-dependent trans- methylation processes, where adenosine, an obligatory product, has to be constantly removed. Homozygous Adk~-/- mutants de- veloped normally during embryogenesis.

机译：新生儿肝脂肪变性（OMIM 228100）是一种病因不明的致命疾病，其特征是肝脏苍白，发黄，出生后早期死亡。在本研究中，腺苷依赖的代谢缺陷被认为是病因。在生理上，腺苷被腺苷激酶（ADK）有效地代谢为AMP，ADK是一种在肝脏中高度表达的酶。 ADK不仅可以确保正常的腺嘌呤核苷酸水平，而且对于维持S-腺苷甲硫氨酸依赖的甲基化过程至关重要，在该过程中，腺苷（一种必不可少的产物）必须不断去除。纯合的Adk〜-/-突变体在胚胎发生过程中正常发育。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2002年第10期|p.6985-6990|共6页
作者
Detlev Boison; Louis Scheurer; Valerie Zumsteg;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Neonatal hepatic steatosis by disruption of the adenosine kinase gene [J] . Detlev Boison, Louis Scheurer, Valerie Zumsteg, Proceedings of the National Academy of Sciences of the United States of America . 2002,第10期

机译：腺苷激酶基因的破坏导致新生儿肝脂肪变性
2. Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones. [J] . Hwahng SH, Ki SH, Bae EJ, Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2009,第6期

机译：腺苷单磷酸激活蛋白激酶-p70核糖体S6激酶-1通路在新型一类二硫代硫酮抑制肝X受体-α依赖的脂肪生成基因诱导和肝脂肪变性中的作用。
3. Glycycoumarin prevents hepatic steatosis through activation of adenosine 5,-monophosphate (AMP)-activated protein kinase signaling pathway and up-regulation of BTG1/Tob-1 [J] . Journal of Functional Foods . 2017,第期

机译：Glycycoumarin通过激活腺苷5， - 单磷酸酯（AMP） - 活化的蛋白激酶信号通路和BTG1 / TOB-1的上调来阻止肝脏脂肪变性
4. Transient Exposition to Neonatal Hypothyroidism Increases Hepatic Gene Expression of Suppressors of Cytokine Signaling (SOCS) During Catch-Up Growth and in Adulthood [C] . Mirecki-Garrido M., Fernez-Perez L. European Congress of Pharmacology . 2012

机译：新生儿甲状腺功能减退症的瞬态阐述增加了在追赶生长和成年期间细胞因子信号传导（SOC）抑制剂的肝基因表达
5. Pyruvate dehydrogenase kinase 4 deficiency and hepatic steatosis. [D] . Hwang, Byounghoon. 2009

机译：丙酮酸脱氢酶激酶4缺乏症和肝脂肪变性。
6. Neonatal hepatic steatosis by disruption of the adenosine kinase gene [O] . Detlev Boison, Louis Scheurer, Valérie Zumsteg, 2002

机译：腺苷激酶基因的破坏导致新生儿肝脂肪变性
7. Neonatal hepatic steatosis by disruption of the adenosine kinase gene [O] . Boison, Detlev, Scheurer, Louis, Zumsteg, Valérie, 2002

机译：腺苷激酶基因的破坏导致新生儿肝脂肪变性

Neonatal hepatic steatosis by disruption of the adenosine kinase gene

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