The OhrR repressor senses organic hydroperoxides by reversible formation of a cysteine-sulfenic acid derivative

Mayuree Fuangthong; John D. Helmann

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The OhrR repressor senses organic hydroperoxides by reversible formation of a cysteine-sulfenic acid derivative

机译：OhrR阻遏物通过可逆地形成半胱氨酸-磺酸衍生物来检测有机氢过氧化物

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Reactive oxygen species induce the expression of detoxification and repair genes critical for life in an aerobic environment. Bacterial factors that sense reactive oxygen species use either thiol-disulfide exchange reactions (OxyR, RsrA) or redox labile 2Fe-2S clusters (SoxR). We demonstrate that the reduced form of Bacillus subtilis OhrR binds cooperatively to two adjacent inverted repeat sequences in the ohrA control region and thereby represses transcription. In the presence of organic hydroperoxides, OhrR is inactivated by the reversible oxidation of a single conserved cysteine residue to the corresponding cysteine-sulfenic acid, and perhaps to higher oxidation states.

机译：活性氧可诱导排毒表达并修复有氧环境中生命至关重要的基因。感测活性氧的细菌因子使用硫醇-二硫键交换反应（OxyR，RsrA）或氧化还原不稳定的2Fe-2S簇（SoxR）。我们证明，枯草芽孢杆菌OhrR的减少形式合作结合到ohrA控制区域中的两个相邻的反向重复序列，从而抑制转录。在有机氢过氧化物的存在下，OhrR通过将单个保守的半胱氨酸残基可逆氧化为相应的半胱氨酸-亚硫酸而失活，并可能变为较高的氧化态。

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2002年第10期|p.6690-6695|共6页
作者
Mayuree Fuangthong; John D. Helmann;
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作者单位

Department of Microbiology, Cornell University, Ithaca, NY 14853-8101;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
peroxide stress; oxidative stress; peroxiredoxin; alkyl hydroperoxide reductase; bacillus subtilis;

机译：过氧化物胁迫;氧化胁迫;过氧化物酶;烷基氢过氧化物还原酶;枯草芽孢杆菌;

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专利

1. The OhrR repressor senses organic hydroperoxides by reversible formation of a cysteine-sulfenic acid derivative [J] . Mayuree Fuangthong, John D. Helmann Proceedings of the National Academy of Sciences of the United States of America . 2002,第10期

机译：OhrR阻遏物通过可逆地形成半胱氨酸-磺酸衍生物来检测有机氢过氧化物
2. Novel Organic Hydroperoxide-Sensing and Responding Mechanisms for OhrR, a Major Bacterial Sensor and Regulator of Organic Hydroperoxide Stress [J] . Warunya Panmanee, Paiboon Vattanaviboon, Leslie B. Poole, Journal of bacteriology . 2006,第4期

机译：OhrR的新型有机过氧化氢传感和响应机制，主要细菌传感器和有机过氧化氢应激调节剂
3. Dual role of OhrR as a repressor and an activator in response to organic hydroperoxides in Streptomyces coelicolor [J] . Oh S.-Y., Shin J.-H., Roe J.-H. Excerpta medica abstract journal . 2007,第7期

机译：OhrR在天蓝色链霉菌中作为有机过氧化氢的阻遏物和活化剂的双重作用
4. Hydroperoxide and organic peroxide formation by ozomation of organic compounds in aqueous solutions [C] . Ernst Gilbert . 1983

机译：水溶液中有机化合物的渗入形成氢过氧化物和有机过氧化物
5. Sensing of organic hydroperoxide by Bacillus subtilis OhrR [D] . Soonsanga, Sumarin. 2007

机译：枯草芽孢杆菌OhrR感测有机氢过氧化物
6. The OhrR repressor senses organic hydroperoxides by reversible formation of a cysteine-sulfenic acid derivative [O] . Mayuree Fuangthong, John D. Helmann 2002

机译：OhrR阻遏物通过可逆地形成半胱氨酸-磺酸衍生物来检测有机氢过氧化物
7. The OhrR repressor senses organic hydroperoxides by reversible formation of a cysteine-sulfenic acid derivative [O] . Fuangthong, Mayuree, Helmann, John D. 2002

机译：OhrR阻遏物通过可逆地形成半胱氨酸-磺酸衍生物来检测有机氢过氧化物
8. The Vibrational Spectra and Structures of Organic Acids and Their Derivatives. 1. Bromoacetic Acid and Sodium Bromoacetate. [R] . katon,john e. kleinlein,ronald l. 1974

机译：有机酸及其衍生物的振动光谱和结构。 1.溴乙酸和溴乙酸钠。

The OhrR repressor senses organic hydroperoxides by reversible formation of a cysteine-sulfenic acid derivative

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