Genome-wide screening for trait conferring genes using DNA microarrays

R. T. Gill; S. Wildt; Y. T. Yang

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Genome-wide screening for trait conferring genes using DNA microarrays

机译：使用DNA芯片对全基因组进行特质赋予基因筛选

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We report a DNA microarray-based method for genome-wide monitoring of competitively grown transformants to identify genes whose overexpression confers a specific cellular phenotype. Whereas transcriptional profiling identifies differentially ex- pressed genes that are correlated with particular aspects of the cellular phenotype, this functional genomics approach determines genes that result in a specific physiology. This parallel gene-trait mapping method consists of transforming a strain with a genomic library, enriching the cell population in transformants containing the trait conferring gene(s), and finally using DNA microarrays to simultaneously isolate and identify the enriched gene inserts.

机译：我们报告了一种基于DNA微阵列的方法，可用于竞争性生长转化子的全基因组监测，以鉴定其过表达赋予特定细胞表型的基因。转录谱鉴定出与细胞表型特定方面相关的差异表达基因，而这种功能基因组学方法确定了导致特定生理学的基因。这种平行的基因-特征作图方法包括用基因组文库转化菌株，在含有赋予特征的基因的转化子中富集细胞群体，最后使用DNA微阵列同时分离和鉴定富集的基因插入片段。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2002年第10期|p.7033-7038|共6页
作者
R. T. Gill; S. Wildt; Y. T. Yang;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Genome-wide screening for trait conferring genes using DNA microarrays [J] . R.T. Gill, S. Wildt, Y. T. Yang, Proceedings of the National Academy of Sciences of the United States of America . 2002,第10期

机译：使用DNA芯片对全基因组进行特质赋予基因筛选
2. A genome-wide association study of social and non-social autistic-like traits in the general population using pooled DNA, 500 K SNP microarrays and both community and diagnosed autism replication samples. [J] . Ronald A, Butcher LM, Docherty Behavior Genetics: An International Journal Devoted to Research in the Inheritance of Behavior in Animals and Man . 2010,第1期

机译：使用汇集的DNA，500 K SNP芯片以及社区和诊断出的自闭症复制样本，对普通人群中的社会和非社会自闭症样特征进行全基因组关联研究。
3. A Genome-Wide Association Study of Social and Non-Social Autistic-Like Traits in the General Population Using Pooled DNA, 500 K SNP Microarrays and Both Community and Diagnosed Autism Replication Samples [J] . Angelica Ronald, Lee M. Butcher, Sophia Docherty, Behavior Genetics . 2010,第1期

机译：使用汇集的DNA，500 K SNP芯片以及社区和诊断出的自闭症复制样本对普通人群中的社会和非社会自闭症样特征进行全基因组关联研究
4. Cloning of Genes Conferring Allergenic Proteins and Salt Tolerance by Screening a Full Length cDNA Library in Soybean [C] . Yuelin Zhu, Lifei Yang, Junyi Gai International Horticulture Congress on Science and Horticulture for People . 2012

机译：通过在大豆中筛选全长cDNA文库赋予过敏蛋白和耐盐性基因的克隆
5. Genome-wide DNA microarray analysis of RNA transcript lengths in yeast and man. [D] . Hurowitz, Evan. 2005

机译：酵母和人中RNA转录长度的全基因组DNA微阵列分析。
6. Genome-wide screening for trait conferring genes using DNA microarrays [O] . R. T. Gill, S. Wildt, Y. T. Yang, 2002

机译：使用DNA芯片对全基因组进行特质赋予基因筛选
7. Genome-wide screening for trait conferring genes using DNA microarrays [O] . Gill, R. T., Wildt, S., Yang, Y. T., 2002

机译：使用DNA芯片对全基因组进行特质赋予基因筛选
8. Genome-Wide Identified Risk Variant for PTSD is a Methylation Quantitative Trait Locus and Confers Decreased Cortical Activation to Fearful Faces. [R] . Almli, L. M., Stevens, J. S., Smith, A. K., 2015

机译：pTsD的全基因组鉴定风险变异是甲基化数量性状基因座并且赋予恐惧面部皮质激活减少。

Genome-wide screening for trait conferring genes using DNA microarrays

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