Antitumor activity of cytotoxic T lymphocytes engineered to target vascular endothelial growth factor receptors

Thomas M. J. Niederman; Zoher Ghogawala; Bob S. Carter

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Antitumor activity of cytotoxic T lymphocytes engineered to target vascular endothelial growth factor receptors

机译：靶向血管内皮生长因子受体的细胞毒性T淋巴细胞的抗肿瘤活性

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The demonstration that angiogenesis is required for the growth of solid tumors has fueled an intense interest in the development of new therapeutic strategies that target the tumor vasculature. Here we report the development of an immune-based antiangiogenic strategy that is based on the generation of T lymphocytes that possess a killing specificity for cells expressing vascular endothelial growth factor receptors (VEGFRs). To target VEGFR-expressing cells, recombinant retroviral vectors were generated that encoded a chimeric T cell receptor comprised of VEGF sequences linked to intracellular signaling sequences derived from the chain of the T cell receptor.

机译：实体瘤生长需要血管生成的论证引起了对靶向肿瘤脉管系统的新治疗策略的发展的强烈兴趣。在这里，我们报告了基于免疫的抗血管生成策略的发展，该策略基于T淋巴细胞的产生，该T淋巴细胞对表达血管内皮生长因子受体（VEGFR）的细胞具有杀伤特异性。为了靶向表达VEGFR的细胞，产生了重组逆转录病毒载体，其编码由VEGF序列组成的嵌合T细胞受体，所述VEGF序列与衍生自T细胞受体链的细胞内信号传导序列连接。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2002年第10期|p.7009-7014|共6页
作者
Thomas M. J. Niederman; Zoher Ghogawala; Bob S. Carter;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Antitumor activity of cytotoxic T lymphocytes engineered to target vascular endothelial growth factor receptors [J] . Thomas M. J. Niederman, Zoher Ghogawala, Bob S. Carter, Proceedings of the National Academy of Sciences of the United States of America . 2002,第10期

机译：靶向血管内皮生长因子受体的细胞毒性T淋巴细胞的抗肿瘤活性
2. A human IgG-like bispecific antibody co-targeting epidermal growth factor receptor and the vascular endothelial growth factor receptor 2 for enhanced antitumor activity [J] . Chen Zhiguo, Xie Wei, Acheampong Desmond Omane, Cancer biology & therapy . 2016,第2期

机译：共同靶向表皮生长因子受体和血管内皮生长因子受体2的人IgG类双特异性抗体，可增强抗肿瘤活性
3. A novel bispecific diabody targeting both vascular endothelial growth factor receptor 2 and epidermal growth factor receptor for enhanced antitumor activity [J] . Xu Menghuai, Jin Haizhen, Chen Zhiguo, Biotechnology Progress . 2016,第2期

机译：靶向血管内皮生长因子受体2和表皮生长因子受体的新型双特异性双价抗体，具有增强的抗肿瘤活性
4. Vascular endothelial growth factor receptor 2 binding peptide:Targeting vascular endothelial cells [C] . Laimute Taraseviciene-stewart, John M.Stewart, Lajos Gera, European Peptide Symposium . 2002

机译：血管内皮生长因子受体2结合肽：靶向血管内皮细胞
5. Vascular Endothelial Growth Factor (VEGF) Presentation Modulates Endothelial Cell Signaling and Vascular Branching in engineered matrices in vitro and in vivo. [D] . Gojgini, Shiva. 2014

机译：血管内皮生长因子（VEGF）的表达可在体内和体外调节工程基质中的内皮细胞信号传导和血管分支。
6. Antitumor activity of cytotoxic T lymphocytes engineered to target vascular endothelial growth factor receptors [O] . Thomas M. J. Niederman, Zoher Ghogawala, Bob S. Carter, 2002

机译：靶向血管内皮生长因子受体的细胞毒性T淋巴细胞的抗肿瘤活性
7. Antitumor activity of cytotoxic T lymphocytes engineered to target vascular endothelial growth factor receptors [O] . Niederman, Thomas M. J., Ghogawala, Zoher, Carter, Bob S., 2002

机译：靶向血管内皮生长因子受体的细胞毒性T淋巴细胞的抗肿瘤活性

Antitumor activity of cytotoxic T lymphocytes engineered to target vascular endothelial growth factor receptors

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