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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression
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Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression

机译：通过靶向TCL1表达在小鼠中模拟人慢性淋巴细胞性白血病

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摘要

The TCL1 gene at 14q32.1 is involved in chromosomal transloca- tions and inversions in mature T cell leukemias. These leukemias are classified either as T prolymphocytic leukemias, which occur very late in life, or as T chronic lymphocytic leukemias, which often arise in patients with ataxia telangiectasia (AT) at a young age. In transgenic animals, the deregulated expression of TCL1 leads to mature T cell leukemia, demonstrating the role of TCL1 in the initiation of malignant transformation in T cell neoplasia. Expres- sion of high levels of Tcl1 have also been found in a variety of human tumor-derived B cell lines ranging from pre-B cell to mature B cell.
机译：14q32.1处的TCL1基因参与成熟T细胞白血病的染色体易位和倒置。这些白血病既可以归类为T淋巴细胞性白血病（发生时间很晚），也可以归类为T慢性淋巴细胞性白血病，通常在年轻时患有共济失调性毛细血管扩张症（AT）的患者中出现。在转基因动物中，TCL1的表达失调导致成熟的T细胞白血病，这表明TCL1在T细胞瘤形成的恶性转化中起着重要作用。从前B细胞到成熟B细胞，从人类肿瘤衍生的B细胞系中也发现了高水平的Tcl1表达。

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