Looped out and perpendicular: Deformation of Watson-Crick base pair associated with actinomycin D binding

Shan-Ho Chou; Ko-Hsin Chin; Fu-Ming Chen

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Looped out and perpendicular: Deformation of Watson-Crick base pair associated with actinomycin D binding

机译：环状且垂直：与放线菌素D结合相关的Watson-Crick碱基对的变形

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Many anticancer drugs interact directly with DNA to exert their biological functions. To date, all noncovalent, intercalating drugs interact with DNA exclusively by inserting their chromophores into base steps to form elongated and unwound duplex structures without disrupting the flanking base pairs. By using actinomycin D (ActD)-5'-GXC/CYG-5' complexes as examples, we have found a rather unusual interaction mode for the intercalated drug; the central Watson-Crick X/Y base pairs are looped out and displaced by the ActD chromophore. The looped-out bases are not disor- dered but interact perpendicularly with the base/chromophore and form specific H bonds with DNA.

机译：许多抗癌药物直接与DNA相互作用以发挥其生物学功能。迄今为止，所有非共价插入药物都仅通过将其发色团插入碱基步骤以形成拉长和解链的双链体结构而不会破坏侧翼碱基对的方式与DNA相互作用。以放线菌素D（ActD）-5'-GXC / CYG-5'复合物为例，我们发现了插层药物的一种非常不寻常的相互作用方式。中心的Watson-Crick X / Y碱基对被ActD生色团环化并置换。环状碱基并没有被破坏，而是与碱基/发色团垂直相互作用，并与DNA形成特定的H键。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2002年第10期|p.6625-6630|共6页
作者
Shan-Ho Chou; Ko-Hsin Chin; Fu-Ming Chen;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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专利

1. Looped out and perpendicular: Deformation of atson-Crick base pair associated with actinomycin D binding [J] . Shan-Ho Chou, Ko-Hsin Chin, Fu-Ming Chen Proceedings of the National Academy of Sciences of the United States of America . 2002,第10期

机译：环状且垂直：与放线菌素D结合相关的atson-Crick碱基对的变形
2. Quantum Chemical Studies of Structures and Binding in Noncanonical RNA Base pairs: The Trans Watson-Crick:Watson-Crick Family. [J] . Sharma P, Mitra A, Sharma S, Journal of Biomolecular Structure and Dynamics . 2008,第6期

机译：非经典RNA碱基对中结构和结合的量子化学研究：Trans Watson-Crick：Watson-Crick家族。
3. Unique actinomycin D binding to self-complementary d(CXYGGCCY'X'G) sequences: duplex disruption and binding to a nominally base-paired hairpin [J] . Fu-Ming Chen, Feng Sha, Ko-Hsin Chin, Nucleic Acids Research . 2003,第14期

机译：独特的放线菌素D与自身互补d（CXYGGCCY'X'G）序列的结合：双链断裂并与标称碱基配对的发夹结合
4. DNA-binding characteristics of two analogs of actinomycin D:5,5'-Val_2-AMD and 2,2'-Phe_2-AMD [C] . Rui Wang, Jing-Man Ni, Xiao-Wu Yang, Chinese peptide symposium . 1998

机译：两种运动霉素D的DNA结合特征D：5,5'-Val_2-AMD和2,2'-PHE_2-AMD
5. Sequence dependence of stabilities and structures of tandem mismatches and Watson-Crick base pairs in RNA. [D] . Xia, Tianbing. 1999

机译：RNA中串联错配和Watson-Crick碱基对的稳定性和结构的序列依赖性。
6. Looped out and perpendicular: Deformation of Watson–Crick base pair associated with actinomycin D binding [O] . Shan-Ho Chou, Ko-Hsin Chin, Fu-Ming Chen 2002

机译：环形且垂直：与放线菌素D结合相关的沃森-克里克碱基对的变形
7. Looped out and perpendicular: Deformation of Watson–Crick base pair associated with actinomycin D binding [O] . Chou, Shan-Ho, Chin, Ko-Hsin, Chen, Fu-Ming 2002

机译：环形且垂直：与放线菌素D结合相关的沃森-克里克碱基对的变形

Looped out and perpendicular: Deformation of Watson-Crick base pair associated with actinomycin D binding

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