Negative selection of thymocytes expressing the D10 TCR

Derek B. SantAngelo; Charles A. Janeway Jr.

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Negative selection of thymocytes expressing the D10 TCR

机译：阴性选择表达D10 TCR的胸腺细胞

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We have analyzed the patterns of positive and negative selection of thymocytes expressing the T cell antigen receptor (TCR) from the D10.G4.1 T cell clone. This TCR confers reactivity to several non-self MHC class II alleles with a remarkably broad range of avidities. Therefore, negative selection can be studied when induced by high-, intermediate-, or low-avidity interactions with endogenous peptide-MHC complexes, all within the same TCR transgenic sys- tem. These data directly demonstrate that MHC class II-peptide ligands that fail to activate mature T cells can promote negative selection of immature thymocytes.

机译：我们已经分析了从D10.G4.1 T细胞克隆中表达T细胞抗原受体（TCR）的胸腺细胞的阳性和阴性选择模式。该TCR赋予多个非自身的MHC II类等位基因以显着广泛的亲和力。因此，当与内源性肽-MHC复合物的高，中或低亲和力相互作用诱导时，可以研究阴性选择，所有这些都在同一TCR转基因系统中进行。这些数据直接证明未能激活成熟T细胞的MHC II类肽配体可促进未成熟胸腺细胞的阴性选择。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2002年第10期|p.6931-6936|共6页
作者
Derek B. SantAngelo; Charles A. Janeway Jr.;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Negative selection of thymocytes expressing the D10 TCR [J] . Derek B. SantAngelo, Charles A. Janeway Jr. Proceedings of the National Academy of Sciences of the United States of America . 2002,第10期

机译：阴性选择表达D10 TCR的胸腺细胞
2. Recognition of a specific self-peptide: self-MHC class II complex is critical for positive selection of thymocytes expressing the D10 TCR. [J] . Dao T, Blander JM, SantAngelo DB The Journal of Immunology: Official Journal of the American Association of Immunologists . 2003,第1期

机译：特定自身肽的识别：II类自身MHC复合物对于阳性选择表达D10 TCR的胸腺细胞至关重要。
3. Positive selection of thymocytes expressing the same TCR by different MHC ligands results in the production of functionally distinct thymocytes distinguished by differential expression of the heat stable antigen. [J] . Teh HS, Motyka B, Teh SJ The Journal of Immunology: Official Journal of the American Association of Immunologists . 1998,第2期

机译：通过不同的MHC配体对表达相同TCR的胸腺细胞进行阳性选择会导致产生功能不同的胸腺细胞，这些胸腺细胞以热稳定抗原的差异表达为特征。
4. Nonlinear cooperation between p53 and ING1 induces bax expression in mouse thymocyte apoptosis [C] . Shaojin Duan, Hongxiao Liu, Yuxia Chen, The 7th Asia-Pacific Bioinformatics Conference（第七届亚太生物信息学大会） . 2009

机译：p53和ING1之间的非线性合作诱导小鼠胸腺细胞凋亡中的bax表达
5. The molecular mechanism of Nur77/Nor-1 induced apoptosis of thymocytes undergoing negative selection. [D] . Thompson, Jennifer. 2009

机译：Nur77 / Nor-1诱导经历负选择的胸腺细胞凋亡的分子机制。
6. Negative selection of thymocytes expressing the D10 TCR [O] . Derek B. SantAngelo, Charles A. Janeway Jr. 2002

机译：阴性选择表达D10 TCR的胸腺细胞
7. Negative selection of thymocytes expressing the D10 TCR [O] . Sant'Angelo, Derek B., Janeway, Charles A. 2002

机译：阴性选择表达D10 TCR的胸腺细胞

Negative selection of thymocytes expressing the D10 TCR

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