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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Short-term antigen presentation and single clonal burst limit the magnitude of the CD8+ T cell responses to malaria liver stages
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Short-term antigen presentation and single clonal burst limit the magnitude of the CD8+ T cell responses to malaria liver stages

机译：短期抗原呈递和单个克隆爆发限制了CD8 + T细胞对疟疾肝阶段反应的幅度

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摘要

Malaria sporozoites induce swift activation of antigen-specific CD8+ T cells that inhibit the intracellular development of liver-stage parasites. The length of time of functional in vivo antigen presentation, estimated by monitoring the activation of antigen-specific CD8+ T cells, is of short duration, with maximum T cell activation occurring within the first 8 h after immunization and lasting approximately 48 h. Although the magnitude of the CD8+ Tcell response closely correlates with the number of parasites used for immunization, increasing the time of antigen presentation by daily immunizations does not enhance the magnitude of this response. Thus, once a primary clonal burst is established, the CD8+ T cell response becomes refractory or unresponsive to further antigenic stimulation. These findings strongly suggest that the most efficient strategy for the induction of primary CD8+ T cell responses is the delivery of a maximal amount of antigen in a single dose, thereby ensuring a clonal burst that involves the largest number of precursors to become memory cells.
机译：疟疾子孢子诱导抗原特异性CD8 + T细胞的迅速活化，从而抑制肝阶段寄生虫的细胞内发育。通过监测抗原特异性CD8 + T细胞的活化作用来估计体内功能性抗原呈递的时间长度很短，最大的T细胞活化作用发生在免疫后的前8小时内，持续约48小时。尽管CD8 + T细胞反应的强度与用于免疫的寄生虫数量密切相关，但是通过每日免疫增加抗原呈递的时间并不能增强该反应的强度。因此，一旦建立了初级克隆爆发，CD8 + T细胞反应就变得难治或对进一步的抗原刺激无反应。这些发现强烈表明，诱导原代CD8 + T细胞反应的最有效策略是在单次剂量中递送最大量的抗原，从而确保了涉及最大数量前体的克隆爆发成为记忆细胞。

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