首页> 外国专利> mixtures of antigenic peptides or polypeptide, antigenic peptides, antigenic polypeptide, antigenic mixtures, lipopeptide, myxotope, lipomixotope, conjugate, immunogenic compositions, malaria vaccine, use of a mixture, polyclonal serum, recombinant human antibody, uses of a composition, methods and kits for the in vitro diagnosis of malaria, nucleotide sequences, cloning vector and / or recombinant expression, use of a recombinant host cell and DNA expression vector

mixtures of antigenic peptides or polypeptide, antigenic peptides, antigenic polypeptide, antigenic mixtures, lipopeptide, myxotope, lipomixotope, conjugate, immunogenic compositions, malaria vaccine, use of a mixture, polyclonal serum, recombinant human antibody, uses of a composition, methods and kits for the in vitro diagnosis of malaria, nucleotide sequences, cloning vector and / or recombinant expression, use of a recombinant host cell and DNA expression vector

机译：抗原性肽或多肽的混合物，抗原性肽，抗原性多肽，抗原性混合物，脂肽，黏附体，脂质混合体，缀合物，免疫原性组合物，疟疾疫苗，混合物的使用，多克隆血清，重组人抗体，组合物的用途，方法和试剂盒用于体外诊断疟疾，核苷酸序列，克隆载体和/或重组表达，使用重组宿主细胞和DNA表达载体

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"Peptide mixtures or polypeptide antigen, peptide antigen, polypeptide antigen, mixtures antigenic, lipopeptide, MIXOTOPO, LIPOMIXOTOPO, conjugate, compositions immunogenic, VACCINE AGAINST MALARIA, OF A MIX USE, polyclonal, antibody HUMAN RECOMBINANT, ONE USES OF COMPOSITION, PRODUCT IN VITRO DIAGNOSTIC DIAGNOSTICS, METHODS AND KITS, NUCLEOTIDE SEQUENCES, CLONING VECTOR AND / OR RECOMBINANT EXPRESSION, USE OF A RECOMBINANT RECOMBINANT DNA CELL AND EXPRESSION VECTOR. The present invention relates to malaria protection. More specifically, the invention is based on the characterization of a novel P. falciparum sporozoite hepatic stage antigen referred to as LSA-5. This antigen is highly antigenic and the predominance of antibodies in individuals residing in endemic areas is extremely high (approximately 90%). The invention relates to antigenic peptides, mixtures thereof, or polypeptides, mixotopes and conjugates comprising part of the LSA-5 sequence, as well as immunogenic compositions, vaccines and kits comprising them.

机译：“肽混合物或多肽抗原，肽抗原，多肽抗原，抗原混合物，脂肽，MIXOTOPO，LIPOMIXOTOPO，缀合物，免疫原性组合物，抗疟疾疫苗，混合使用，多克隆，抗体人重组，一种用途的组合物，体外产品诊断性诊断，方法和试剂盒，核苷酸序列，克隆载体和/或重组表达，重组DNA细胞和表达载体的使用本发明涉及疟疾保护，更具体地，本发明基于新颖的表征恶性疟原虫子孢子肝阶段抗原，称为LSA-5，该抗原是高度抗原性的，并且在流行区域的个体中抗体的优势非常高（约90％）。本发明涉及抗原性肽，其混合物或包含LSA-5序列的一部分的多肽，混合物和共轭物，以及免疫原性组合物，疫苗和包含它们的试剂盒。

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公开/公告号BRPI0417286A

专利类型
公开/公告日2007-04-10

原文格式PDF
申请/专利权人 INSTITUT PASTEUR;
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申请/专利号BR2004PI17286
发明设计人 PIERRE DRUILHE;KARIMA BRAHIMI-ZEGHIDOUR;
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申请日2004-12-15
分类号C07K14/445;A61K39/015;A61K39/39;C07K16/20;C07K17;C07K17/02;
国家 BR
入库时间 2022-08-21 20:59:25

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