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Higher order arrangement of the eukaryotic nuclear bodies

机译：真核细胞核的高阶排列

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The nuclei of eukaryotic cells consist of discrete substructures. These substructures include the nuclear bodies, which have been implicated in a number of biological processes such as transcription and splicing. However, for most nuclear bodies, the details of involvement in these processes in relation to their three-dimensional distributions in the nucleus are still unclear. Through the analysis of TDP, a protein functional in both transcriptional repression and alternative splicing, we have identified a new category of nuclear bodies within which the TDP molecules reside. Remarkably, the TDP bodies (TBs) colocalize or overlap with several different types of nuclear bodies previously suggested to function in transcription or splicing. Of these nuclear bodies, the Gemini of coiled bodies (GEM) seems to associate with TB through the interaction between survival motor neuron (SMN) protein and TDP. Furthermore, TB sometimes appears to be the bridge of two or more of these other nuclear bodies. Our data suggest the existence of a hierarchy and possibly functional arrangement of the nuclear bodies within the eukaryotic nuclei.
机译：真核细胞的核由离散的亚结构组成。这些亚结构包括核小体，这些核小体与许多生物过程有关，例如转录和剪接。但是，对于大多数核机构而言，与这些过程在核中的三维分布有关的参与细节仍然不清楚。通过对TDP的分析，TDP是一种在转录抑制和选择性剪接中均具有功能的蛋白质，我们已经确定了TDP分子所在的一类新的核体。值得注意的是，TDP体（TB）与以前建议在转录或剪接中起作用的几种不同类型的核体共定位或重叠。在这些核小体中，盘绕小体（GEM）的双子座似乎通过生存运动神经元（SMN）蛋白与TDP之间的相互作用与结核相关。此外，结核病有时似乎是两个或多个其他这些核机构的桥梁。我们的数据表明，在真核细胞核中存在着核体的层次结构和可能的功能排列。

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