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Herpes viruses hedge their bets

机译:疱疹病毒对冲他们的赌注

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摘要

Static latency is the hallmark of all herpes viruses. The varicella zoster virus, for instance, causes varicella (chickenpox), and after a latent phase of between 5 and 40 years, it can give rise to herpes zoster (shingles). This latency and the subsequent reactivation has intrigued and puzzled virologists. Although several factors have been suggested, it is unknown what triggers reactivation. However, latency can be explained with a simple evolutionary model. Here, we demonstrate that a simple, yet efficient, bet-hedging strategy might have evolved in a number of viruses, especially those belonging to the herpes virus family and most importantly in varicella zoster virus. We show that the evolution of latency can be explained by the population dynamics of infectious diseases in fluctuating host populations.
机译:静态潜伏期是所有疱疹病毒的标志。例如,水痘带状疱疹病毒会引起水痘(水痘),在潜伏期为5至40年后,它会引起带状疱疹(带状疱疹)。这种潜伏期和随后的重新激活引起了病毒学家的兴趣和困惑。尽管已经提出了几个因素,但是什么触发重新激活是未知的。但是,可以使用简单的演化模型来解释延迟。在这里,我们证明了一种简单但有效的对冲策略可能已经在多种病毒中发展,尤其是属于疱疹病毒家族的病毒,最重要的是在水痘带状疱疹病毒中。我们表明,潜伏期的演变可以通过波动的宿主种群中传染病的种群动态来解释。

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