...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila
【24h】

Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila

机译：果蝇Notch信号转导需要早老素介导的跨膜裂解。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The deavage model for signal transduction by receptors of the LIN-12/Notch family posits that ligand binding leads to cleavage within the transmembrane domain, so that the intracellular do- main is released to translocate to the nucleus and activate target gene expression. The familial Alzheimer's disease-associated pro- tein Presenilin is required for LIN-12/Notch signaling, and several lines of evidence suggest that Presenilin mediates the transmem- brane cleavage event that releases the LlN-12/Notch intracellular domain. However, doubt was cast on this possibility by a report that Presenilin is not required for the transducing activity of N~ECN, a constitutively active transmembrane form of Notch, in Drosoph- ila. Here, we have reassessed this finding and show instead that Presenilin is required for activity of N~ECN for all cell fate decisions examined. Our results indicate that transmembrane cleavage and signal transduction are strictly correlated, supporting the cleavage model for signal transduction by LIN-12/Notch and a role for Presenilin in mediating the ligand-induced transmembrane cleavage.
机译：LIN-12 / Notch家族受体信号转导的破坏模型认为，配体结合会导致跨膜结构域内的裂解，从而释放细胞内结构域以转移至细胞核并激活靶基因表达。 LIN-12 / Notch信号传导需要家族性与阿尔茨海默氏病相关的蛋白，而一些证据表明，早老素介导了跨膜裂解事件，释放了LlN-12 / Notch细胞内结构域。但是，有报道称，在果蝇中，早老蛋白N-ECN（一种Notch的组成型活性跨膜形式）的转导活性并不需要早老素，对此人们对此表示怀疑。在这里，我们已经重新评估了这一发现，并显示了早老素对于所有检测到的细胞命运决定都需要N〜ECN的活性。我们的结果表明跨膜裂解和信号转导是严格相关的，支持LIN-12 / Notch信号转导的裂解模型，以及早老素在介导配体诱导的跨膜裂解中的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号