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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A peripheral marker for schizophrenia: Increased levels of D3 dopamine receptor mRNA in blood lymphocytes
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A peripheral marker for schizophrenia: Increased levels of D3 dopamine receptor mRNA in blood lymphocytes

机译：精神分裂症的周围标志物：血液淋巴细胞中D3多巴胺受体mRNA的水平升高

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Dopamine is a major neurotransmitter in the central nervous system, and its receptors are associated with a number of neuro- pathological disorders such as Parkinson's disease and schizophre- nia. Although the precise pathophysiology of schizophrenia re- mains unknown, the dopaminergic hypothesis of the illness assumes that the illness results from excessive activity at dopamine synapses in the brain. Because, at present, the diagnosis of schizo- phrenia relies on descriptive behavioral and symptomatic infor- mation, a peripheral measurable marker may enable a simpler, more rapid, and more accurate diagnosis and monitoring. In recent years, human peripheral blood lymphocytes have been found to express several dopamine receptors (D_3, D_4, and D_5) by using molecular biology techniques and binding assays. It has been suggested that these dopamine receptors found on lymphocytes may reflect receptors found in the brain. Here we demonstrate a correlation between the D_3 dopamine receptor on lymphocytes and schizophrenia and show a significant elevation of at least 2-fold in the mRNA level of the D_3, but not of the D_4, dopamine receptor in schizophrenic patients. This increase is not affected by different antipsychotic drug treatments (typical or atypical). More- over, nonmedicated patients exhibit the same pattern, indicating that this change is not a result of medical treatment. We propose the D_3 receptor mRNA on blood lymphocytes as a marker for identification and followup of schizophrenia.
机译：多巴胺是中枢神经系统的主要神经递质，其受体与帕金森氏病和精神分裂症等许多神经病理疾病有关。尽管精神分裂症的确切病理生理学仍然未知，但是该疾病的多巴胺能假说假设该疾病是由于大脑中多巴胺突触的过度活动引起的。因为目前，精神分裂症的诊断依赖于描述性的行为和症状信息，所以外周可测量的标记物可以实现更简单，更快速，更准确的诊断和监测。近年来，已经发现通过使用分子生物学技术和结合测定，人类外周血淋巴细胞表达几种多巴胺受体（D_3，D_4和D_5）。已经提出，在淋巴细胞上发现的这些多巴胺受体可能反映在大脑中发现的受体。在这里，我们证明了淋巴细胞上的D_3多巴胺受体与精神分裂症之间的相关性，并显示精神分裂症患者D_3的mRNA水平至少升高了2倍，而D_4多巴胺受体的mRNA水平却没有升高。这种增加不受其他抗精神病药物治疗（典型或非典型）的影响。此外，未接受药物治疗的患者表现出相同的模式，表明这种变化不是药物治疗的结果。我们提出血淋巴细胞上的D_3受体mRNA作为鉴定和随访精神分裂症的标志。

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