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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Progesterone receptor and dopamine receptors are required in △ ~9-tetrahydrocannabinol modulation of sexual receptivity in female rats
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Progesterone receptor and dopamine receptors are required in △ ~9-tetrahydrocannabinol modulation of sexual receptivity in female rats

机译：雌性大鼠的△〜9-四氢大麻酚调节性受体中需要孕酮受体和多巴胺受体

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摘要

Ovarian steroids, estrogen and progesterone, influence the sensitivity Of certain neural processes to cannabinoid treatment by modulation Of brain dopaminergic activity. We examined the effects of the active ingredient of cannabis. △~9-tetrahydrocannabinol (THC), on sexual behavior in female rats and its influence on Steroid hormone recep- tors and neurotransmitters in the facilitation of sexual receptivity. Our results revealed that the facilitatory effect of THC was inhibited by antagonists to both progesterone and dopamine D_1 receptors. To test further the idea that progesterone receptors (PR) and/or dopa- mine receptors (D_1R) in the hypothalamus are required for THC-' facilitated sexual behavior in rodents, antisense and sense oligonu- cleotides to PR and D_1R were administered intracerebroventricularly (ICV) into the third cerebral ventricle of ovariectomized, estradiol benzoate-primed rats. Progesterone- and THC-facilitated sexual be- havior was inhibited in animals treated with antisense oligonucleo- tides to PR or to D_1R. Antagonists to cannabinoid receptor-1 subtype (CB_l), but not to cannabinoid receptor-2 subtype (CB_2) inhibited progesterone- and dopamine-facilitated sexual receptivity in female rats. Our studies indicate that THC acts on the CB_1 cannabinoid receptor to initiate a signal transduction response that requires both membrane dopamine and intracellular progesterone receptors for effective induction of sexual behavior.
机译：卵巢类固醇，雌激素和孕酮通过调节脑多巴胺能活性来影响某些神经过程对大麻素治疗的敏感性。我们检查了大麻有效成分的作用。 △〜9-四氢大麻酚（THC）对雌性大鼠性行为的影响及其对类固醇激素受体和神经递质的影响，有助于促进性接受。我们的结果表明，孕激素和多巴胺D_1受体拮抗剂均抑制THC的促进作用。为了进一步检验认为THC-'促进啮齿类动物性行为需要下丘脑中的孕激素受体（PR）和/或多巴胺受体（D_1R），对脑室内和脑部给予PR和D_1R的反义和有义寡核苷酸（ ICV）进入卵巢切除的雌二醇苯甲酸酯引发的大鼠的第三脑室。在用PR或D_1R反义寡核苷酸治疗的动物中，黄体酮和THC促进的性行为受到抑制。大麻素受体1亚型（CB_1）的拮抗剂，但大麻素受体2亚型（CB_2）的拮抗剂不能抑制雌性大鼠的孕酮和多巴胺促进的性接受性。我们的研究表明，四氢大麻酚作用于CB_1大麻素受体以启动信号转导反应，该信号转导反应需要膜多巴胺和细胞内孕激素受体才能有效地诱导性行为。

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