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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The effects of aging on gene expression in the hypothalamus and cortex of mice
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The effects of aging on gene expression in the hypothalamus and cortex of mice

机译：衰老对小鼠下丘脑和皮层基因表达的影响

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摘要

A better understanding of the molecular effects of aging in the brain may help to reveal important aspects of organismal aging, as well as processes that lead to age-related brain dysfunction. In this study, we have examined differences in gene expression in the hypothalamus and cortex of young and aged mice by using high-density oligonucleotide arrays. A number of key genes in- volved in neuronal structure and signaling are differentially ex- pressed in both the aged hypothalamus and cortex, including synaptotagmin Ⅰ. cAMP-dependent protein kinase C p. apolipopro- tein E, protein phosphatase 2A, and prostaglandin D. Misregula- tion of these proteins may contribute to age-related memory deficits and neurodegenerative diseases. In addition, many pro- teases that play essential roles in regulating neuropeptide metab- olism, amyloid precursor protein processing, and neuronal apo- ptosis are up-regulated in the aged brain and likely contribute significantly to brain aging. Finally, a subset of these genes whose expression is affected by aging are oppositely affected by expo- sure of mice to an enriched environment, suggesting that these genes may play important roles in learning and memory.
机译：更好地了解大脑中衰老的分子效应可能有助于揭示机体衰老的重要方面，以及导致与年龄相关的脑功能障碍的过程。在这项研究中，我们已经通过使用高密度寡核苷酸阵列检查了年轻和老年小鼠下丘脑和皮层中基因表达的差异。在老年下丘脑和皮层中差异表达许多涉及神经元结构和信号传导的关键基因，包括突触结合蛋白Ⅰ。 cAMP依赖性蛋白激酶C p。载脂蛋白E，蛋白磷酸酶2A和前列腺素D。这些蛋白的调节异常可能会导致与年龄相关的记忆缺陷和神经退行性疾病。此外，许多在调节神经肽代谢，淀粉样前体蛋白加工和神经元凋亡中起重要作用的蛋白在老年人的大脑中被上调，并可能对脑衰老起重要作用。最后，这些基因的表达受衰老影响的子集受到小鼠暴露于丰富环境的相反影响，表明这些基因可能在学习和记忆中起重要作用。

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