...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >From cell death to embryo arrest: Mathematical models of human preimplantation embryo development
【24h】

From cell death to embryo arrest: Mathematical models of human preimplantation embryo development

机译：从细胞死亡到胚胎停滞：人类植入前胚胎发育的数学模型

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Human preimplantation embryos exhibit high levels of apoptotic cells and high rates of developmental arrest during the first week in vitro. The relation between the two is unclear and difficult to determine by conventional experimental approaches, partly be- cause of limited numbers of embryos. We apply a mixture of experiment and mathematical modeling to show that observed levels of cell death can be reconciled with the high levels of embryo arrest seen in the human only if the developmental competence of embryos is already established at the zygote stage, and environ- mental factors merely modulate this. This suggests that research on improving in vitro fertilization success rates should move from its current concentration on optimizing culture media to focus more on the generation of a healthy zygote and on understanding the mechanisms that cause chromosomal and other abnormalities during early cleavage stages.
机译：在体外的第一周中，人类植入前的胚胎表现出高水平的凋亡细胞和高发育停滞率。两者之间的关系尚不清楚，并且难以通过常规实验方法确定，部分原因是胚胎数量有限。我们采用实验和数学模型的混合方法，表明只有在合子阶段已经建立了胚胎的发育能力并且环境健康的情况下，观察到的细胞死亡水平才能与人类中观察到的高水平的胚胎停滞相协调。因素只是调节这一点。这表明，关于提高体外受精成功率的研究应从目前的注意力转移到优化培养基上，以更多地关注健康合子的产生以及对卵裂早期阶段染色体及其他异常机制的理解。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号