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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells
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Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells

机译：gp130激活在促有丝分裂刺激的小鼠造血干细胞促进自我更新分裂中的不同作用

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摘要

Previous studies have demonstrated hematopoietic stem cell am- plification in vitro after the activation of three cell-surface recep- tors: flt3/flk2. c-kit, and gp130. We now show flt3-ligand and Steel factor alone will stimulate >85/100 of c-kit~+Sca-1~+lin-- adult mouse hone marrow cells to proliferate in single-cell serum-free cultures, but concomitant retention of their stem cell activity requires additional exposure to a ligand that will activate gp130. Moreover, this response is restricted to a narrow range of gp130-activating ligand concentrations, above and below which hematopoietic stem cell activity is lost. These findings indicate a unique contribution of gp130 signaling to the maintenance of hematopoietic stem cell function when these cells are stimulated to divide with additional differential effects dictated by the intensity of gp130 activation.
机译：先前的研究表明，在激活三种细胞表面受体：flt3 / flk2后，体外可进行造血干细胞扩增。 c-kit和gp130。我们现在显示，单独的flt3-配体和钢因子会刺激> 85/100的c-kit〜+ Sca-1〜+ lin--成年小鼠骨髓细胞在单细胞无血清培养物中增殖，但同时保留它们的干细胞活性需要额外接触会激活gp130的配体。此外，该反应被限制在gp130激活配体浓度的狭窄范围内，高于和低于该浓度，造血干细胞活性丧失。这些发现表明，当这些细胞被刺激分裂时，gp130信号传导对维持造血干细胞功能的独特贡献，这些差异由gp130激活的强度决定。

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