Oligomerization of the integrin αIIbβ3: Roles of the transmembrane and cytoplasmic domains

Renhao Li; Charles R. Babu; James D. Lear

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Oligomerization of the integrin αIIbβ3: Roles of the transmembrane and cytoplasmic domains

机译：整联蛋白αIIbβ3的低聚：跨膜和胞质域的作用

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Integrins are a family of α/β heterodimeric membrane proteins, which mediate cell-cell and cell-matrix interactions. The molecular mechanisms by which integrins are activated and cluster are currently poorly understood. One hypothesis posits that the cyto- plasmic tails of the α and β subunits interact strongly with one another in a 1:1 interaction, and that this interaction is modulated in the course of the activation of αIIbβ3 [Hughes, P. E., et al. (1996) J. Biol. Chem. 271, 6571-6574]. To examine the structural basis for this interaction, protein fragments encompassing the transmem- brane helix plus cytoplasmic tails of the α and β subunits of αIIbβ3 were expressed and studied in phospholipid micelles at physio- logical salt concentrations.

机译：整联蛋白是α/β异二聚体膜蛋白家族，其介导细胞-细胞和细胞-基质相互作用。目前尚不清楚整合素被激活和聚集的分子机制。一种假设认为，α和β亚基的细胞质尾巴以1：1的相互作用彼此强烈相互作用，并且这种相互作用在αIIbβ3的活化过程中受到调节[Hughes，P.E.，等人。（1996）生物化学杂志。化学271，6571-6574]。为了检验这种相互作用的结构基础，表达了蛋白质片段，该片段包含跨膜螺旋以及αIIbβ3的α和β亚基的细胞质尾巴，并在磷脂胶束中以生理盐浓度进行了研究。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2001年第22期|p.12462-12467|共6页
作者
Renhao Li; Charles R. Babu; James D. Lear;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Structure of an integrin αIIbβ3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation [J] . Jun Yang, Yan-Qing Ma, Richard C Page, Proceedings of the National Academy of Sciences of the United States of America . 2009,第42期

机译：整合素αIIbβ3跨膜-胞质异质复合物的结构提供了整合素激活的见解。
2. Implications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function [J] . Zhenwei Lu, Sijo Mathew, Jiang Chen, eLife journal . 2016,第4期

机译：β1和β3跨膜和胞质结构域对整联蛋白功能的不同作用的暗示
3. Palmitoylated peptide, being derived from the carboxyl-terminal sequence of the integrin alpha(IIb) cytoplasmic domain, inhibits talin binding to alpha(IIb)beta(3) [J] . Gkourogianni Alexia, Egot Marion, Koloka Vassiliki, Platelets . 2014,第8期

机译：棕榈酸酯化肽，源自整联蛋白α（IIb）细胞质域的羧基末端序列，可抑制塔林蛋白与α（IIb）beta（3）的结合
4. Homo-oligomerization of transmembrane α-domain of integrin [C] . Shamloo Amir, Nikbin Ehsan, Mehboudi Nastaran, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2014

机译：整联蛋白跨膜α结构域的均聚
5. The role of the transmembrane and cytoplasmic domains of the VPU protein of human immunodeficiency virus type 1 (HIV-1) in the acute CD4+ T cell loss and disease in the simian human immunodeficiency virus (SHIV)/macaque model. [D] . Hout, David Richard. 2006

机译：人类免疫缺陷病毒1型（HIV-1）的VPU蛋白的跨膜和胞质域在猿猴人类免疫缺陷病毒（SHIV）/猕猴模型的急性CD4 + T细胞丧失和疾病中的作用。
6. Oligomerization of the integrin αIIbβ3: Roles of the transmembrane and cytoplasmic domains [O] . Renhao Li, Charles R. Babu, James D. Lear, 2001

机译：整联蛋白αIIbβ3的低聚：跨膜和胞质域的作用
7. Oligomerization of the integrin αIIbβ3: Roles of the transmembrane and cytoplasmic domains [O] . Li, Renhao, Babu, Charles R., Lear, James D., 2001

机译：整联蛋白αIIbβ3的低聚：跨膜和胞质域的作用
8. Functional Analysis of Alpha-6 Integrin Cytoplasmic Domains [R] . Domanico, S. Z., Quaranta, V. 1995

机译：α-6整合素细胞质结构域的功能分析

Oligomerization of the integrin αIIbβ3: Roles of the transmembrane and cytoplasmic domains

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