The expression of theγ subunit of Na-K-ATPase is regulated by osmolality via C-terminal Jun kinase and phosphatidylinositol 3-kinase- dependent mechanisms

J. M. Capasso; C. Rivard; T. Berl

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The expression of theγ subunit of Na-K-ATPase is regulated by osmolality via C-terminal Jun kinase and phosphatidylinositol 3-kinase- dependent mechanisms

机译：Na-K-ATPaseγ亚基的表达受渗透压的调节，途径是C端Jun激酶和磷脂酰肌醇3激酶依赖性机制

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Theα andβ subunits of Na-K-ATPase are up-regulated by hyper- tonicity in inner-medullary collecting duct cells adapted to survive in hypertonic conditions. We examined the regulation of theγ subunit by hypertonicity. Although cultured inner-medullary col- lecting duct cells lacked theγ subunits, both variants γ_a and γ_b were expressed in cells adapted to 600 and 900 mosmol/KgH_2O. This expression was reversible with a half-time of 17.2 ± 0.5 h. The message of theγ subunit was absent in isotonic conditions and increased with higher tonicity in adapted cells.

机译：Na-K-ATPase的α和β亚基通过高渗性在适于在高渗条件下生存的髓内收集导管细胞中上调。我们检查了高渗性对γ亚基的调节。尽管培养的髓内集合管细胞缺乏γ亚基，但两种变体γ_a和γ_b均在适应于600和900 mosmol / KgH_2O的细胞中表达。该表达是可逆的，半场时间为17.2±0.5 h。在等渗条件下不存在γ亚基的信息，并且在适应细胞中随着更高的张力而增加。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2001年第23期|p.13414-13419|共6页
作者
J. M. Capasso; C. Rivard; T. Berl;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. The expression of the γ subunit of Na-K-ATPase is regulated by osmolality via C-terminal Jun kinase and phosphatidylinositol 3-kinase-dependent mechanisms [O] . J. M. Capasso, C. Rivard, T. Berl 2001

机译：渗透压通过C端Jun激酶和磷脂酰肌醇3-激酶依赖性机制调节Na-K-ATP酶γ亚基的表达
7. The expression of the γ subunit of Na-K-ATPase is regulated by osmolality via C-terminal Jun kinase and phosphatidylinositol 3-kinase-dependent mechanisms [O] . Capasso, J. M., Rivard, C., Berl, T. 2001

机译：渗透压通过C端Jun激酶和磷脂酰肌醇3-激酶依赖性机制调节Na-K-ATP酶γ亚基的表达

The expression of theγ subunit of Na-K-ATPase is regulated by osmolality via C-terminal Jun kinase and phosphatidylinositol 3-kinase- dependent mechanisms

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