Betawrap: Successful prediction of parallel β-helices from primary sequence reveals an association with many microbial pathogens

Phil Bradley; Lenore Cowen; Matthew Menke

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Betawrap: Successful prediction of parallel β-helices from primary sequence reveals an association with many microbial pathogens

机译：Betawrap：从一级序列成功预测平行β-螺旋揭示了与许多微生物病原体的关联

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The amino acid sequence rules that specify β-sheet structure in proteins remain obscure. A subclass of β-sheet proteins, parallel β-helices, represent a processive folding of the chain into an elongated topologically simpler fold than globular β-s heets. In this paper, we present a computational approach that predicts the right-handed parallel βhelix supersecondary structural motif in primary amino acid sequences by using β-strand interactions learned from non-β-helix structures. A program call ed BETAWRAP (Http.//theory.lcs.mit/betawrap)) implements this method and recognizes each of the seven known parallel β-helix families, when trained on the known parallel β-helices from outside that family.

机译：在蛋白质中指定β-折叠结构的氨基酸序列规则仍然不清楚。 β-折叠蛋白的一个亚类，平行的β-螺旋，代表链的逐步折叠，形成比球形β-sheets更长的拓扑简单折叠。在本文中，我们提出了一种计算方法，该方法通过使用从非β螺旋结构中获悉的β链相互作用来预测一级氨基酸序列中右手平行的β螺旋超二级结构基序。名为BETAWRAP（Http.//theory.lcs.mit/betawrap）的程序实现了此方法，并在该族以外的已知平行β螺旋上进行训练时，可以识别七个已知的平行β螺旋家族中的每一个。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2001年第26期|p.14819-14824|共6页
作者
Phil Bradley; Lenore Cowen; Matthew Menke;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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2. Significant Association between Sulfate-Reducing Bacteria and Uranium-Reducing Microbial Communities as Revealed by a Combined Massively Parallel Sequencing-Indicator Species Approach [J] . Erick Cardenas, Wei-Min Wu, Mary Beth Leigh, Applied Microbiology . 2010,第20期

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3. Significant Association between Sulfate-Reducing Bacteria and Uranium-Reducing Microbial Communities as Revealed by a Combined Massively Parallel Sequencing-Indicator Species Approach [J] . Erick Cardenas, Wei-Min Wu, Mary Beth Leigh, Applied and Environmental Microbiology . 2010,第20期

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4. Computational predictions of host-pathogen interactions using domain and sequence signature [C] . Dibyajyoti Das, Sowmya Ramaswamy Krishnan, Gopalakrishnan Bulusu, IEEE International Conference on Bioinformatics and Biomedicine . 2019

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5. The specific amino acid sequence between putative helices 7 and 8 of human apolipoprotein A-I influences HDL subclass association and generation. [D] . Carnemolla, Ronald, Jr. 2009

机译：人载脂蛋白A-1的推定螺旋7和8之间的特定氨基酸序列影响HDL亚类的缔合和产生。
6. betawrap: Successful prediction of parallel β-helices from primary sequence reveals an association with many microbial pathogens [O] . Phil Bradley, Lenore Cowen, Matthew Menke, 2001

机译：betawrap：并行的成功预测来自初级序列的β-螺旋揭示了与许多微生物病原体
7. betawrap: Successful prediction of parallel β-helices from primary sequence reveals an association with many microbial pathogens [O] . Bradley, Phil, Cowen, Lenore, Menke, Matthew, 2001

机译：betawrap：并行的成功预测来自初级序列的β-螺旋揭示了与许多微生物病原体

Betawrap: Successful prediction of parallel β-helices from primary sequence reveals an association with many microbial pathogens

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