Chip interacts with diverse homeodomain proteins and potentiates Bicoid activity in vivo

Emi Torigoi; ldriss M. Bennani-Baitit; Christina Rosent

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Chip interacts with diverse homeodomain proteins and potentiates Bicoid activity in vivo

机译：芯片与多种同源异域结构域蛋白相互作用，并增强体内的类比活性

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The Drosophila protein Chip potentiates activation by several enhancers and is required for embryonic segmentation. Chip and its mammalian homologs interact with and promote dimerization of nuclear LIM proteins. No known Drosophila LIM proteins. how- ever. are required for segmentation, nor for expression of most genes known to be regulated by Chip. Here we show that Chip also interacts with diverse homeodomain proteins using residues dis- tinct from those that interact with LlM proteins, and that Chip potentiates activity of one of these homeodomain proteins in DrosoPhiIa embryos and in yeast. These and other observations help explain the roles of Chip in segmentation and suggest a model to explain how Chip potentiates activation by diverse enhancers.

机译：果蝇蛋白芯片增强了几种增强剂的激活，是胚胎分割所必需的。 Chip及其哺乳动物同源物与核LIM蛋白相互作用并促进其二聚化。没有已知的果蝇LIM蛋白。但是。是分割所必需的，也不是已知受Chip调控的大多数基因的表达所必需的。在这里，我们表明Chip还使用与L1M蛋白相互作用的残基截然不同的残基与各种Homeodomain蛋白相互作用，并且Chip增强了果蝇胚胎和酵母中这些Homeodomain蛋白之一的活性。这些和其他观察结果有助于解释Chip在细分中的作用，并提出一个模型来解释Chip如何增强各种增强子的激活作用。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2000年第6期|p.2686-2691|共6页
作者
Emi Torigoi; ldriss M. Bennani-Baitit; Christina Rosent;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM-homeodomain protein complexes in vivo. [J] . Van Meyel DJ, Agulnick AD Development . 2003,第9期

机译：Ssdp蛋白与LIM相互作用的辅因子结合，并在体内调节LIM-同源结构蛋白复合物的活性。
2. The activity of the Drosophila morphogenetic protein Bicoid is inhibited by a domain located outside its homeodomain. [J] . Zhao C, York A, Yang F, Development . 2002,第7期

机译：果蝇形态发生蛋白Bicoid的活性被位于其同源域外部的域抑制。
3. Targeted Disruption of the Murine Homeodomain-Interacting Protein Kinase-2 Causes Growth Deficiency In Vivo and Cell Cycle Arrest In Vitro (Retraction of vol 28, pg 161, 2009) [J] . Trapasso Francesco DNA and Cell Biology . 2014,第3期

机译：有针对性的破坏小鼠的Homeodomain相互作用蛋白激酶2导致体内生长缺陷和体外细胞周期阻滞（第28卷撤消，第161页，2009年）
4. Dynamic behaviour of water in the DNA-Protein Interface of the Antennapedia homeodomain-DNA complex [C] . Sujata Roy, Ashoke Ranjan Thakur International Conference on Bioinformatics, Computational Biology, Genomics and Chemoinformatics . 2010

机译：antionapedia homodomain-dna复合物DNA-蛋白质界面中水的动态行为
5. NMR solution structure of the bicoid homeodomain bound to DNA and molecular dynamics simulations of the homeodomain/DNA complex. [D] . Baird-Titus, Jamie M. 2005

机译：核糖体同源域结合到DNA的NMR溶液结构以及同源域/ DNA复合体的分子动力学模拟。
6. Chip interacts with diverse homeodomain proteins and potentiates Bicoid activity in vivo [O] . Emi Torigoi, Idriss M. Bennani-Baïti, Christina Rosen, 2000

机译：芯片与多种同源结构域蛋白相互作用并增强类比活性在体内
7. Chip interacts with diverse homeodomain proteins and potentiates Bicoid activity in vivo [O] . Torigoi, Emi, Bennani-Baïti, Idriss M., Rosen, Christina, 2000

机译：芯片与多种同源结构域蛋白相互作用并增强类比活性在体内

Chip interacts with diverse homeodomain proteins and potentiates Bicoid activity in vivo

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