HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors

Stephen A. Miquelest; M. Shirin Sabbaqhiant; W. Lesley Shupert

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HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors

机译：HLA B * 5701与HIV感染的长期非进展者亚组中病毒复制的限制高度相关

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Aunique cohort of HlV-1 -infected long term nonprogressors (LTNP) with normal CD4+ T cell counts and < 50 copies/ml of plasma were prospectively recruited for study. HLA typing revealed a dramatic association between the HLA B*5701 class l allele and nonprogres- sive infection [85/100 (11 of 13) vs. 9.5/100 (19 of 200) in progressors; P < 0.0011. Antigen-specific CD8+ T cells were enumerated by flow ofometric detection of intracellular IFN-y in response to HIV antigens and HLA B*57-gag tetramer staining. No quantitative differences in the total HlV-specific CD8+ T cell responses were observed between B*S7+ LTNP and five B*57+ progressors (P = , 0.4). Although similar frequencies of peptide specific CD8+ T cells were also found.

机译：前瞻性招募了一组具有正常CD4 + T细胞计数且血浆<50拷贝/ ml的HlV-1感染的长期非进展者（LTNP）。 HLA分型显示HLA B * 5701 I类等位基因与进展性非进展性感染之间的显着相关性[85/100（13之11）与9.5 / 100（19之200）]。 P ＜0.0011。通过对HIV抗原应答的细胞内IFN-γ和HLA B * 57-gag四聚体染色的流式检测来枚举抗原特异性CD8 + T细胞。在B * S7 + LTNP与5个B * 57 +进行细胞之间，未观察到总的HIV特异性CD8 + T细胞反应的定量差异（P = 0.4）。尽管也发现了类似的肽特异性CD8 + T细胞频率。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2000年第6期|p.2709-2714|共6页
作者
Stephen A. Miquelest; M. Shirin Sabbaqhiant; W. Lesley Shupert;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Recognition of the highly conserved YMDD region in the human immunodeficiency virus type 1 reverse transcriptase by HLA-A2-restricted cytotoxic T lymphocytes from an asymptomatic long-term nonprogressor. [J] . Harrer E, Harrer T, Barbosa P, The Journal of Infectious Diseases . 1996,第2期

机译：人类免疫缺陷病毒1型逆转录酶中高度保守的YMDD区域被无症状长期非进展者的HLA-A2限制性细胞毒性T淋巴细胞识别。
2. Maintenance of large numbers of virus-specific CD8+ T cells in HIV-infected progressors and long-term nonprogressors. [J] . Gea Banacloche-JC, Migueles SA, Martino L, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2000,第2期

机译：在HIV感染的进展者和长期非进展者中维持大量病毒特异性CD8 + T细胞。
3. Maintenance of Large Numbers of Virus-Specific CD8+ T Cells in HIV-Infected Progressors and Long-Term Nonprogressors [J] . Juan C. Gea-Banacloche, Stephen A. Migueles, Lisa Martino, The journal of immunology . 2000,第2期

机译：在HIV感染的进展者和长期非进展者中维持大量病毒特异的CD8 + T细胞
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6. HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors [O] . Stephen A. Migueles, M. Shirin Sabbaghian, W. Lesley Shupert, 2000

机译：HLA B * 5701与病毒限制高度相关在感染艾滋病毒的长期非进展者亚组中复制
7. HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors [O] . Migueles, Stephen A., Sabbaghian, M. Shirin, Shupert, W. Lesley, 2000

机译：HLA B * 5701与病毒限制高度相关在感染艾滋病毒的长期非进展者亚组中复制
8. Interactions between HIV-Infected Monocytes and the Extracellular Matrix:Increased Capacity of HIV-Infected Monocytes to Adhere to and Spread on Extracellular Matrix Associated with Changes in Extent of Virus Replication and Cytopathic Effects in Infected [R] . Dhawan, S., Vargo, M., Meltzer, M. S. 1992

机译：HIV感染的单核细胞与细胞外基质之间的相互作用：HIV感染的单核细胞增加容纳和扩散细胞外基质的能力与病毒复制程度和感染细胞病变效应的变化相关

HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors

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