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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The inhibitory effect of hormones associated with stress on Na appetite of sheep
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The inhibitory effect of hormones associated with stress on Na appetite of sheep

机译：应激相关激素对绵羊食欲的抑制作用

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Stress is a large stimulus of Na appetite in rabbits, rats, and mice. - This study investigated the influence of some peptides implicated in stress. i.e.. adrenocorticotropin (ACTH). corticotropin-releasing factor (CRF), and the recently discovered member of the CRF family, urocortin, on the ingestive behavior of sheep. Intracerebroventric- ular infusion of these peptides over 4 days decreased the need-free Na intake of Na-repleted sheep. Intracerebroventricular infusion of urocortin, however, did not alter Na intake of Na-depleted sheep. Systemic infusion of ACTH increased, whereas systemic infusion of either urocortin or CRF decreased, Na intake of Na-repleted sheep. The increase in Na intake caused by the peripheral infusion of ACTH was blocked by concurrent i.v. infusion of urocortin, substantiating the inhibitory role of this peptide on Na appetite. Central admin- istration of all peptides and i.v. administration of urocortin or urocortin and ACTH combined decreased food intake. Water intake was not directly influenced by the peptides. Rather. decreased water intake, when observed. was secondary to decreased food intake. as determined by pair-feeding experiments. Whereas sys- temic infusion of ACTH mimics the increase in Na intake observed in several different stressful situations. CRF and urocortin actually inhibit Na intake. indicating a direct central action overriding any effect of these peptides on ACTH release. Indeed. the inhibition of Na intake by urocortin occurred despite its stimulation of ACTH release and the subsequent increase in peripheral level of cortisol. Thus it would appear that hormones associated with stress have both excitatory and inhibitory influences on Na intake. Presum- ably, other physiological processes entrained by stress also will be important in determining the quantitative outcome on Na appetite.
机译：压力是对兔子，大鼠和小鼠的食欲大的刺激。 -这项研究调查了一些与应激有关的肽的影响。即肾上腺皮质激素（ACTH）。促肾上腺皮质激素释放因子（CRF），以及最近发现的CRF家族成员urocortin对绵羊的摄食行为。经脑室内输注这些肽超过4天，减少了Na重饲绵羊的Na摄入量。脑室注入尿皮质激素并没有改变缺钠绵羊的钠摄入量。全身输注ACTH增加，而尿皮质激素或CRF全身输注减少，Na重复摄入的绵羊的Na摄入量增加。并发静脉内注射阻止了ACTH周边输注引起的钠摄入量增加。输注尿皮质激素，证实该肽对食欲不振的抑制作用。所有肽和i.v.的集中管理尿皮质素或尿皮质素与ACTH联合给药可减少食物摄入。进水不受肽直接影响。相反。观察时水摄入量减少。继发于食物摄入减少。由配对喂养实验确定。而全身性ACTH输注模仿了在几种不同压力情况下钠摄入量的增加。 CRF和尿皮质素实际上抑制了钠的摄入。指示直接的中枢作用，而不是这些肽对ACTH释放的任何作用。确实。尽管尿皮质素刺激了ACTH释放并随后增加了皮质醇的外周水平，但仍抑制了尿皮质素对钠的摄入。因此，似乎与压力有关的激素对钠的摄入具有兴奋性和抑制性影响。据推测，压力引起的其他生理过程对于确定食欲的定量结果也很重要。

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