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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Selective in vivo suppression of T lymphocyte responses in experimental measles virus infection
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Selective in vivo suppression of T lymphocyte responses in experimental measles virus infection

机译：选择性抑制实验性麻疹病毒感染中T淋巴细胞反应

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摘要

During and after measles virus (MV) infection humans are highly susceptibIe to opportunistic infections because of a marked immu- nosuppressive effect of the virus. The mechanisms by which the virus induces this phenomenon is not well understood. In partic- ular, detailed information is missing on the targets of suppression in relation to antigen-specific T and B cell responses. Because such studies require animal experiments, we used the cotton rat model, in which the MV causes a respiratory tract infection. Primary as well as secondary T cell responses were impaired in vivo and ex vivo by MV infection. The proliferation of T cells was greatly reduced. but their effector functions. such as cytolysis or cytokine secretion, were not. In contrast, primary and secondary B cell responses in vivo as measured by the frequency of antigen-specific plasma cells in an enzyme-linked immunospot (ELlSPOT) assay were not altered by MV infection. Only the secretion of immunoglobulins was reduced slightly in animaIs primarily infected with MV after 2 weeks. These data demonstrate that MV-induced immunosuppres- sion acts primarily on the T cell responses in vivo.
机译：在麻疹病毒（MV）感染期间和之后，由于该病毒具有显着的免疫抑制作用，因此人类很容易受到机会性感染的影响。病毒诱导这种现象的机制尚不清楚。特别是，缺少有关抗原特异性T和B细胞反应的抑制目标的详细信息。由于此类研究需要动物实验，因此我们使用了棉鼠模型，其中的MV导致呼吸道感染。 MV感染在体内和离体损害了初级和次级T细胞应答。 T细胞的增殖大大减少。但它们的效应子功能。如细胞溶解或细胞因子分泌，均未发生。相比之下，MV感染不会改变在酶联免疫斑点（EL1SPOT）分析中通过抗原特异性浆细胞的频率测量的体内初级和次级B细胞反应。在最初感染MV的动物2周后，仅免疫球蛋白的分泌略有减少。这些数据表明，MV诱导的免疫抑制主要作用于体内T细胞反应。

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