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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Rapid pole-to-pole oscillation of a protein required for direct division to the middle of Escherichia coli
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Rapid pole-to-pole oscillation of a protein required for direct division to the middle of Escherichia coli

机译：直接分裂到大肠杆菌中间所需的蛋白质的快速极点振荡

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摘要

Accurate placement of the division septum at the midpoint of Escherichia coli cells requires the combined action of a general division inhibitor (MinC), a site-specific suppressor of division inhibition (MinE), and an ATPase (MinD) that is required for proper functioning of both MinC and MinE. We previously showed that a functional MinE-Gfp fusion accumulates in a ring structure atear the middle of cells. Here we show that functional Gfp-MinD accumulates alternately in either one of the cell halves in what appears to be a rapidly oscillating membrane association-dissociation cycle imposed by MinE. The results indicate that MinD represents a novel type of dynamic cellular element in bacte- ria, with multiple roles in directing the division apparatus to the middle of the cell.
机译：在大肠杆菌细胞的中点正确放置分裂间隔需要通用分裂抑制剂（MinC），分裂抑制的位点特异性抑制剂（MinE）和正常功能所需的ATPase（MinD）的共同作用MinC和MinE。我们以前表明，功能性MinE-Gfp融合物会在细胞中间/附近形成环形结构。在这里，我们显示功能性Gfp-MinD在似乎由MinE施加的快速振荡的膜缔合-解离循环的任一细胞半部中交替积累。结果表明，MinD代表了细菌中一种新型的动态细胞元件，在将分裂装置引导至细胞中间具有多种作用。

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