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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Conservation of sequence and structure flanking the mouse and human #beta#-globin loci: The #beta#-globin genes are embedded within an array of odorant receptor genes
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Conservation of sequence and structure flanking the mouse and human #beta#-globin loci: The #beta#-globin genes are embedded within an array of odorant receptor genes

机译：小鼠和人类＃beta＃-球蛋白基因座侧翼的序列和结构的保守性：＃beta＃-球蛋白基因嵌入在一系列气味受体基因中

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摘要

In mouse and human, the #beta#-globin genes reside in a linear array that is associated with a positive regulatory element located 5' to the genes known as the locus control region (LCR). The sequences of the mouse and human #beta#-globin LCRs are homologous, indicating conservation of an essential function in #beta#-globin gene regulation. We have se- quenced regions flanking the #beta#-globin locus in both mouse and human and found that homology associated with the LCR is more extensive than previously known, making up a con- served block of approx=40 kb. In addition, we have identified DNaseI-hypersensitive sites within the newly sequenced re- gions in both mouse and human, and these structural features also are conserved. Finally, we have found that both mouse and human #beta#-globin loci are embedded within an array of odorant receptor genes that are expressed in olfactory epithe- lium, and we also identify an olfactory receptor gene located 3' of the #beta#-globin locus in chicken. The data demonstrate an evolutionarily conserved genomic organization for the #beta#p-glo- bin locus and suggest a possible role for the #beta#-globin LCR in control of expression of these odorant receptor genes and/or the presence of mechanisms to separate regulatory signals in different tissues.
机译：在小鼠和人类中，＃beta＃-珠蛋白基因位于线性阵列中，该线性阵列与位于基因的5'端的正调控元件相关联，该基因称为基因座控制区（LCR）。小鼠和人＃beta＃-球蛋白LCR的序列是同源的，表明在＃beta＃-球蛋白基因调节中基本功能的保守性。我们在小鼠和人类的＃beta＃-球蛋白基因座旁都找到了序列区域，发现与LCR相关的同源性比以前已知的更为广泛，构成了约40kb的保守区。此外，我们已经在小鼠和人类的新测序区域中鉴定了DNaseI的超敏位点，并且这些结构特征也得以保留。最后，我们发现小鼠和人类的＃beta＃-球蛋白基因座均嵌入在嗅觉上皮中表达的一系列气味受体基因中，并且我们还鉴定了位于＃beta＃的3'处的嗅觉受体基因。 -鸡肉中的球蛋白基因座。数据证明了＃beta＃p-球蛋白基因座在进化上保守的基因组组织，并暗示了＃beta＃-球蛋白LCR在控制这些气味受体基因的表达和/或存在分离机制方面的可能作用。不同组织中的调节信号。

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