Estimation of Affinity of HLA-A*0201 Restricted CTL Epitope Based on the SCORE Function

Lin Zhi-Hua Wang Huai-Liang Zhu Bo Wang Yuan-Qiang Lin Yong Wu Yu-Zhang

首页> 外文期刊>Protein and Peptide Letters >Estimation of Affinity of HLA-A*0201 Restricted CTL Epitope Based on the SCORE Function

【24h】

Estimation of Affinity of HLA-A*0201 Restricted CTL Epitope Based on the SCORE Function

机译：基于SCORE函数的HLA-A * 0201限制性CTL表位亲和力估计

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A set of 70 peptides with affinity for the class I MHC HLA-A*0201 molecule was subjected to quantitative analyses of structure-affinity relationship based on the SCORE function with good results (r2=0.6982, q2=0.6188, RMS=0.280). Then the ‘leave-one-out’ cross-validation (LOO-CV) and an outer test set including 18 outer samples were used to validate the QSAR model, and the results show that the QSAR model has good predictability for outside samples. Statistical analysis showed that the hydrophobic and hydrogen bond interaction played a significant role in peptide-MHC molecule binding. The study also provided useful information for structure modification of CTL epitope, and laid theoretical base for molecular design of therapeutic vaccine.

机译：对一组对I类MHC HLA-A * 0201分子具有亲和力的肽进行了基于SCORE函数的结构亲和关系的定量分析，结果良好（r2 = 0.6982，q2 = 0.6188，RMS = 0.280）。然后，采用“留一法”交叉验证（LOO-CV）和包含18个外部样本的外部测试集来验证QSAR模型，结果表明QSAR模型对于外部样本具有良好的可预测性。统计分析表明，疏水键和氢键相互作用在肽-MHC分子结合中起着重要作用。该研究还为CTL表位的结构修饰提供了有用的信息，为治疗性疫苗的分子设计奠定了理论基础。

著录项

来源
《Protein and Peptide Letters》 |2009年第5期|p.561-569|共9页
作者
Lin Zhi-Hua Wang Huai-Liang Zhu Bo Wang Yuan-Qiang Lin Yong Wu Yu-Zhang;
展开▼
作者单位

College of Bioengineering, Chongqing Institute of Technology, Chongqing 400050, PR China.;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词
SCORE function, HLA-A*0201, CTL epitope, Affinity, QSAR;

机译：SCORE功能;HLA-A * 0201;CTL表位;亲和力;QSAR;

相似文献

外文文献
中文文献
专利

1. A novel method to estimate the affinity of HLA-A*0201 restricted CTL epitope [J] . Xu YS, Lin Y, Zhu B, Journal of Molecular Structure . 2009,第1a3期

机译：一种估计HLA-A * 0201限制性CTL表位亲和力的新方法
2. A rapid method for quantitative prediction of high affinity CTL epitopes: QSAR studies on peptides having affinity with the class I MHC molecular HLA-A~*0201 [J] . Zhihua Lin, Yuzhang Wu, Yunlong Wei, Letters in peptide science: LIPS . 2003,第1期

机译：快速定量预测高亲和力CTL表位的方法：对与I类MHC分子HLA-A〜* 0201具有亲和力的肽进行QSAR研究
3. A modified HLA-A^(*)0201-restricted CTL epitope from human oncoprotein (hPEBP4) induces more efficient antitumor responses [J] . Weihong Sun, Junyi Shi, Jian Wu, 细胞与分子免疫学：英文版 . 2018,第008期

机译：来自人癌蛋白（HPEBP4）的改性HLA-A ^（*）限制CTL表位诱导更有效的抗肿瘤反应
4. Prediction of HLA-A*0201 Restricted Cytotoxic T Lymphocyte Epitopes in Influenza A H1N1 Virus and the Similarity Analysis of These Epitopes with Those Existing in Other Influenza Viruses [C] . Wang Fei-peng, He Xian-hui 2010 4th International Conference on Bioinformatics and Biomedical Engineering . 2010

机译：H1N1流感病毒中HLA-A * 0201限制性细胞毒性T淋巴细胞表位的预测以及这些表位与其他流感病毒中存在的表位的相似性分析
5. Combined structural and functional approach for identifying new human MHC class I-restricted viral CTL epitopes in vivo [D] . Cheuk, Eve Sik-Yu 2006

机译：结合结构和功能的方法在体内鉴定新的人类MHC I类限制性病毒CTL表位
6. A modified HLA-A*0201-restricted CTL epitope from human oncoprotein (hPEBP4) induces more efficient antitumor responses [O] . Weihong Sun, Junyi Shi, Jian Wu, 2018

机译：人类癌蛋白（hPEBP4）修饰的HLA-A * 0201限制性CTL表位诱导更有效的抗肿瘤反应
7. HLA-A*0201-restricted CTL epitopes in Rv0350 and Rv0351 of latent Mycobacterium tuberculosis [O] . Y. Sun, Y. Wang, H. Wang, 2014

机译：潜伏的结核分枝杆菌Rv0350和Rv0351中的HLa-a * 0201限制性CTL表位
8. CTL-Tumor Cell Interaction: The Generation of Molecular Probes Capable of Monitoring the HLA-A*0201-HER-2/neu Peptide Complex [R] . Ko, E. C. 2007

机译：CTL-肿瘤细胞相互作用：能够监测HLa-a * 0201-HER-2 / neu肽复合物的分子探针的产生

Estimation of Affinity of HLA-A*0201 Restricted CTL Epitope Based on the SCORE Function

摘要

著录项

相似文献

相关主题

期刊订阅