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首页> 外文期刊>Psychological medicine >Obsessive-compulsive disorder, tics and anxiety in 6-year-old twins.
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Obsessive-compulsive disorder, tics and anxiety in 6-year-old twins.

机译：6岁双胞胎强迫症，抽动症和焦虑症。

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BACKGROUND: Previous reports of genetic influences on obsessive-compulsive disorder (OCD) symptoms have suggested moderate heritability. Family history studies of co-morbidity have found familial aggregation with tics, especially for early-onset OCD, and familial aggregation with anxiety disorders. METHOD: Heritability of OCD and familial aggregation of OCD, tics and anxiety disorders were investigated in a community sample of 6-year-old twins using a two-phase design in which 4662 twin pairs were sampled and 854 pairs were assessed in the second phase by maternal-informant diagnostic interview using DSM-IV criteria. RESULTS: In the multivariate model combined additive genetic and common environmental effects were estimated as 47% for sub-threshold OCD, and the model was unable to distinguish these sources of familial aggregation. There were strong familial aggregations between sub-threshold OCD and tics and between sub-threshold OCD and other anxiety disorders (80% and 97% respectively), although again specific sources could not be distinguished. CONCLUSIONS: The findings are consistent with the hypothesis of a tic-related early-onset OCD phenotype, but also with the hypothesis of an anxiety-related early-onset OCD phenotype.
机译：背景：先前关于强迫症（OCD）症状的遗传影响的报告表明，遗传力中等。合并症的家族史研究发现，抽动会导致家族性聚集，尤其是对于早发性强迫症，而焦虑症会导致家族性聚集。方法：采用两阶段设计，在一个6岁双胞胎的社区样本中调查了强迫症的遗传力和强迫症的家族性聚集，抽动和焦虑症，其中共采样了4662对，第二阶段评估了854对。使用DSM-IV标准进行产妇信息诊断性访谈。结果：在多变量模型中，亚阈值强迫症的加性遗传效应和共同环境效应估计为47％，该模型无法区分这些家族聚集的来源。在亚阈值强迫症和抽动之间，以及在亚阈值强迫症和其他焦虑症之间有很强的家族聚集性（分别为80％和97％），尽管不能再次区分出具体的来源。结论：该发现与抽动相关的早发性强迫症表型的假设相符，也与焦虑相关的早发性强迫症表型的假设相符。

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