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首页> 外文期刊>Psychological medicine >A direct interview family study of obsessive-compulsive disorder. II. Contribution of proband informant information.
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A direct interview family study of obsessive-compulsive disorder. II. Contribution of proband informant information.

机译：对强迫症的直接访谈家庭研究。二。先证先知信息的贡献。

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Background. Overall findings of our first direct interview family study of obsessive-compulsive disorder (OCD) indicated that OCD is familial. In this replication study, we carefully examined the role of informant data in ascertaining OCD in relatives. Method. We interviewed 112 relatives of 57 OCD patients and 115 relatives of 41 not ill controls predominantly by telephone. Additional analyses included a combined sample of relatives about whom any diagnostic information was available (228 OCD and 239 controls). To examine the contribution of proband information about relatives, we considered two sets of best-estimate diagnoses. First, we ascertained best-estimate diagnoses for relatives using information from direct interviews and from all informants except the proband. Then, we re-diagnosed relatives based on all available information, including reports from the proband about their relatives. Results. When relative diagnoses were derived without the benefit of proband informant reports, no evidence of familial OCD transmission was found. When diagnoses were made including information from the proband about the relative, evidence of familial OCD was found, but only when the diagnostic threshold was lowered to include cases with probable OCD or OCD symptoms. Other diagnoses (generalized anxiety disorder, social phobia, drug use disorder) were also higher among OCD relatives. Conclusions. This second study provides less robust support for familial transmission of OCD. Evidence for familial transmission of OCD was found only when diagnoses were made using information from the affected proband about their relatives. Taken in context of past findings, our own inconsistent results suggest that OCD may be heterogeneous with regard to familial transmission. Also, more careful attention should be paid to the contribution of informant reports, especially from relatives affected by the same disorder.
机译：背景。我们对强迫症（OCD）进行的首次直接访谈家庭研究的总体结果表明，强迫症是家族性的。在这项复制研究中，我们仔细检查了知情者数据在确定亲属中强迫症中的作用。方法。我们主要通过电话采访了57名强迫症患者的112名亲戚和41名未患病对照的115名亲戚。其他分析还包括可以得到任何诊断信息的亲戚样本（228个OCD和239个对照）。为了检查有关亲戚的先证信息的贡献，我们考虑了两组最佳估计的诊断。首先，我们使用直接访谈和除先证者以外的所有被告的信息确定对亲属的最佳估计诊断。然后，我们根据所有可用信息（包括来自先证者有关亲戚的报告）对亲戚进行重新诊断。结果。如果在没有先证者报告的情况下得出相对诊断，则没有发现家族性强迫症传播的证据。当做出诊断，包括来自先证者的有关亲戚的信息时，就发现了家族性OCD的证据，但是只有当诊断阈值降低到包括可能的OCD或OCD症状的病例时，才发现。在强迫症亲属中，其他诊断（广泛性焦虑症，社交恐惧症，药物滥用症）也较高。结论。第二项研究为强迫症的家族传播提供了较弱的支持。仅当使用受影响的先证者有关其亲属的信息进行诊断时，才发现强迫症家族传播的证据。根据过去的发现，我们自己不一致的结果表明强迫症在家族传播方面可能是异质的。此外，应更加谨慎地关注举报人的举报，尤其是受到同一疾病影响的亲戚的举报。

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