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首页> 外文期刊>Psychological medicine >A direct interview family study of obsessive-compulsive disorder. I.
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A direct interview family study of obsessive-compulsive disorder. I.

机译：对强迫症的直接访谈家庭研究。一世。

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Background. This and the companion paper present two sequential family studies of obsessive-compulsive disorder (OCD) conducted by the same research group, but with different sampling and best-estimate procedures. In addition to providing further data on familial transmission of OCD, we used comparison of disparate findings (moderate, specific familial aggregation in this first study versus a stronger effect for other anxiety disorders than for OCD alone in the second) to examine possible effects of proband characteristics and informant data on outcome. Method. In this initial study we interviewed 179 first-degree relatives of 72 OCD probands and 112 relatives of 32 never mentally ill (NMI) controls. Informant data were obtained on an additional 126 relatives (total 'combined' samples of 263 and 154 respectively). Analyses used best-estimate diagnoses made by consensus of two 'blinded' senior clinicians who reviewed all diagnostic materials including proband informant data about relatives. Results. Significantly higher risk for OCD but not other anxiety disorders was found in relatives of OCD probands compared to relatives of controls in both the directly interviewed and combined samples. There was no relationship between proband age at onset of OCD and strength of familial aggregation. Conclusions. These data indicate moderate familial aggregation of OCD, but do not support increased transmission by early onset probands, or a familial relationship between OCD and other anxiety disorders with the possible exception of generalized anxiety disorder.
机译：背景。本论文和随附的论文介绍了由同一研究小组进行的强迫症（OCD）的两个系列家庭研究，但抽样和最佳估计程序不同。除了提供有关强迫症的家族传播的进一步数据外，我们还使用了不同发现的比较（在第一项研究中中等程度的特定家族聚集与在第二项研究中对其他焦虑症的疗效比单独的强迫症更强）来检验先证者的可能作用。特征和关于结果的线人数据。方法。在这项初步研究中，我们采访了72个强迫症先证者的179个一级亲属和32个从不患精神病（NMI）对照的112个亲属。在另外的126个亲戚（分别为263个和154个“合并”样本）上获得了信息量。分析使用的是由两名“盲人”高级临床医生的共识做出的最佳估计诊断，他们审查了所有诊断材料，包括有关亲戚的先证者信息。结果。在直接访谈和合并样本中，与对照者的亲戚相比，在强迫症先证者的亲戚中发现强迫症的风险高，但未发现其他焦虑症。在强迫症发作时先证者年龄与家族聚集强度之间没有关系。结论。这些数据表明OCD有中等程度的家族性聚集，但不支持早发先证者传播增加，或OCD与其他焦虑症之间的家族关系，但可能存在广泛性焦虑症。

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