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Study of the addictive potential of modafinil in naive and cocaine-experienced rats

机译：莫达非尼对幼稚和可卡因大鼠的成瘾潜力的研究

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摘要

Rationale. Modafinil is a drug that promotes wakefulness and, as such, is used to treat hypersomnia and narcolepsy. Preclinical and clinical studies suggest that modafinil could possess weak reinforcing effects in drug-experienced subjects. However, its abuse potential in drug-naive healthy individuals is still totally uninvestigated, despite the fact that availability of modafinil has recently increased.Objectives: The purpose of our studynwas to investigate the potential addictive properties ofnmodafinil by testing its reinforcing effects in naive rats.nThe interactions of modafinil with the reinforcing effectsnof cocaine were also tested. Methods: First, using i.v.nself-administration and place conditioning tests, we studiednthe reinforcing and rewarding effects of a large rangenof doses of modafinil in naive rats. Second, we tested theninfluence of modafinil on reinforcing and incentive effectsnof cocaine in rats trained for cocaine self-administration.nThe effects of modafinil were compared withnthose of amphetamine and haloperidol. Results: Modafinilndid not produce reinforcing or rewarding effects andndid not modify the effects of cocaine. Conclusions: Ournresults suggest that modafinil does not possess an addictivenpotential in naive individuals. Furthermore, it wouldnbe behaviorally distinct from classical central nervousnsystem stimulants which are known to alter cocaine-inducedneffects. However, as shown previously in nonhumannprimates and in humans, modafinil could possiblynhave reinforcing effects in cocaine-experienced individuals.
机译：基本原理。莫达非尼是一种促进清醒的药物，因此可用于治疗失眠症和发作性睡病。临床前和临床研究表明，莫达非尼在有药物经验的受试者中可能具有较弱的增强作用。然而，尽管最近莫达非尼的可利用性增加了，但仍未对未使用过毒品的健康个体进行滥用的可能性进行研究。 n还研究了莫达非尼与可卡因增强作用的相互作用。方法：首先，通过静脉内自我给药和位置调节测试，我们研究了大剂量莫达非尼对幼稚大鼠的增强和奖励作用。其次，我们测试了莫达非尼对可卡因自我给药训练的大鼠中可卡因的增强和刺激作用的影响。n将莫达非尼与苯丙胺和氟哌啶醇的作用进行了比较。结果：莫达非尼达不产生增强或奖励作用，并且不改变可卡因的作用。结论：我们的结果表明，莫达非尼在幼稚的个体中不具有成瘾性。此外，它在行为上与经典的中枢神经系统兴奋剂不同，后者可改变可卡因引起的影响。但是，如先前在非人类灵长类动物和人类中显示的那样，莫达非尼可能对经历过可卡因的个体没有增强作用。

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  • 来源
    《Psychopharmacology》 |2002年第4期|387-395|共9页
  • 作者

    V. Deroche-Gamonet; M. Darnaudéry; L. Bruins-Slot; F. Piat; M. Le Moal; P. Piazza;

  • 作者单位

    Laboratoire de Psychobiologie des Comportements Adaptatifs Domaine de Carreire Rue Camille Saint-Saëns 33077 Bordeaux France;

    Laboratoire de Psychobiologie des Comportements Adaptatifs Domaine de Carreire Rue Camille Saint-Saëns 33077 Bordeaux France;

    Laboratoire de Psychobiologie des Comportements Adaptatifs Domaine de Carreire Rue Camille Saint-Saëns 33077 Bordeaux France;

    Laboratoire de Psychobiologie des Comportements Adaptatifs Domaine de Carreire Rue Camille Saint-Saëns 33077 Bordeaux France;

    Laboratoire de Psychobiologie des Comportements Adaptatifs Domaine de Carreire Rue Camille Saint-Saëns 33077 Bordeaux France;

    Laboratoire de Psychobiologie des Comportements Adaptatifs Domaine de Carreire Rue Camille Saint-Saëns 33077 Bordeaux France;

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  • 正文语种 eng
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  • 关键词

    Modafinil; Cocaine; Amphetamine; Haloperidol; Place conditioning; Intravenous; self-administration; Dose–response; Progressive ratio; Reinstatement; Rat;

    机译：莫达非尼;可卡因;苯丙胺氟哌啶醇;放置条件;静脉;自我管理;剂量反应;渐进比;复职;鼠;

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