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首页> 外文期刊>Addiction biology >Addictive potential of modafinil and cross-sensitization with cocaine: a pre-clinical study.
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Addictive potential of modafinil and cross-sensitization with cocaine: a pre-clinical study.

机译：莫达非尼的上瘾潜力和与可卡因的交叉致敏作用：临床前研究。

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Repeated or even a single exposure to drugs of abuse can lead to persistent locomotor sensitization, which is the result of an abundance of neuroplastic changes occurring within the circuitry involved in motivational behavior and is thought to play a key role in certain aspects of drug addiction. There is substantial controversy about the addictive potential of modafinil, a wake-promoting drug used to treat narcolepsy that is increasingly being used as a cognitive enhancer and has been proposed as a pharmacotherapy for cocaine dependence. Male mice were used to investigate the ability of modafinil to induce locomotor sensitization after repeated or single administration in mice. Bidirectional cross-sensitization with cocaine and modafinil-induced conditioned place preference were also evaluated. Both repeated and single exposure to moderate and high doses of modafinil produced a pronounced locomotor sensitization that cross-sensitized in a bidirectional way with cocaine. Remarkably, when cocaine and modafinil were repeatedly administered sequentially, their behavioral sensitization was additive. Supporting these behavioral sensitization data, modafinil produced a pronounced conditioned place preference in the mouse. Taken together, the present findings provide pre-clinical evidence for the addictive potential of modafinil. Our data also strongly suggest that similar neural substrates are involved in the psychomotor/rewarding effects of modafinil and cocaine.
机译：重复或什至单次接触滥用药物会导致持续的运动敏化，这是动机行为涉及的回路内发生大量神经塑性变化的结果，被认为在成瘾的某些方面起关键作用。关于莫达非尼的成瘾潜力存在很大争议，莫达非尼是一种用于治疗发作性睡病的促唤醒药物，越来越多地被用作认知增强剂，并已被提议作为可卡因依赖的药物疗法。雄性小鼠用于研究莫达非尼在小鼠中重复或单次给药后诱导运动致敏的能力。还评估了可卡因与莫达非尼诱导的条件性位置偏爱的双向交叉致敏作用。重复和单次暴露于中量和高剂量的莫达非尼都会产生明显的运动致敏作用，并与可卡因双向交叉致敏。值得注意的是，当可卡因和莫达非尼依次重复给药时，它们的行为致敏作用是相加的。支持这些行为敏化数据的莫达非尼在小鼠中产生了明显的条件位置偏好。综上所述，本研究结果为莫达非尼的成瘾潜力提供了临床前证据。我们的数据也强烈表明，类似的神经底物与莫达非尼和可卡因的精神运动/奖励作用有关。

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