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首页> 外文期刊>Quality of Life Research >Health Status in Survivors of Cancer in Childhood and Adolescence
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Health Status in Survivors of Cancer in Childhood and Adolescence

机译：儿童和青少年癌症幸存者的健康状况

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摘要

Background: Assessing health status in survivors of childhood cancer is increasingly important due to improved survival rates. However, there are limited estimates available for this population based on large samples and compared to population controls.Methods: In a retrospective cohort study, 2152 long-term survivors and 2432 controls, aged 5–37, who had survived cancer during childhood or adolescence were compared on the Health Utilities Index Mark III (HUI3). Descriptive and logistic regression analyses were used to assess the effect of age at diagnosis, type of cancer and therapy received on HUI3 domains.Major findings: More survivors than controls showed deficits in dexterity, ambulation, hearing, speech and cognition but not in vision, emotion or pain. The largest numbers of survivors reporting excess impairment was found in the cognition attribute. Survivors of central nervous system tumors were most likely to show impairments across multiple domains. Lastly, impairments in cognition were found most commonly in survivors exposed to cranio-spinal radiation at young ages.Conclusions: Seventy-five percent of childhood cancer survivors and 80% of controls were found to have two or fewer impaired attributes. Those reporting impairments that were most likely to be of clinical relevance were among survivors diagnosed with central nervous system and bone tumours, and those exposed to cranial radiation as young children. Tools assessing health status should be included in prospective trials to more clearly assess the contribution of therapy to reduced long-term health status.
机译：背景：由于生存率提高，评估儿童癌症幸存者的健康状况变得越来越重要。但是，基于大量样本并与人群对照进行比较，该人群的估计有限。方法：在一项回顾性队列研究中，有2152名长期幸存者和2432名5-37岁的对照在儿童或青少年时期幸存了癌症。在健康公用事业指数III（HUI3）上进行了比较。描述性和逻辑回归分析用于评估年龄，诊断类型，所接受的癌症和治疗对HUI3结构域的影响。主要发现：幸存者多于对照者，他们的敏捷度，移动，听觉，言语和认知能力均存在缺陷，但视力没有缺陷；情绪或痛苦。在认知属性中发现报告过度损伤的幸存者数量最多。中枢神经系统肿瘤的幸存者最有可能在多个领域表现出损伤。最后，认知障碍最常见于年轻时暴露于颅骨放射线的幸存者。结论：75％的儿童癌症幸存者和80％的对照者具有两个或更少的受损属性。那些报告最可能与临床相关的损伤的患者是被诊断患有中枢神经系统和骨肿瘤的幸存者，以及那些年幼时暴露于颅骨辐射的患者。评估健康状况的工具应包括在前瞻性试验中，以更清楚地评估治疗对降低长期健康状况的贡献。

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  • 来源
    《Quality of Life Research》 |2006年第1期|143-157|共15页
  • 作者

    Lisa Pogany; Ronald D. Barr; Amanda Shaw; Kathy N. Speechley; Maru Barrera; Elizabeth Maunsell;

  • 作者单位

    Public Health Agency of Canada Centre for Chronic Disease Prevention and Control Ottawa Canada;

    Faculty of Health Sciences McMaster University Hamilton Ontario Canada;

    Public Health Agency of Canada Centre for Chronic Disease Prevention and Control Ottawa Canada;

    Departments of Pediatrics and Epidemiology and Biostatistics The University of Western Ontario and Child Health Research Institute London Ontario Canada;

    Department of Psychology Population Health Sciences Research Institute Hospital for Sick Children and Department of Population Health Sciences Faculty of Medicine University of Toronto Toronto Ontario Canada;

    Department of Social and Preventive Medicine Population Health Research Unit Université Laval Canada;

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  • 正文语种 eng
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  • 关键词

    Adolescent cancer; Cancer survivors; Childhood cancer; Health related quality of life; Health Utilities Index;

    机译：青少年癌症;癌症幸存者;儿童癌症;与健康有关的生活质量;卫生事业指数;

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