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首页> 外文期刊>Radiation and Environmental Biophysics >Incidence of leukaemia and other malignant diseases following injections of the short-lived α-emitter 224Ra into man
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Incidence of leukaemia and other malignant diseases following injections of the short-lived α-emitter 224Ra into man

机译：向人注射短寿命的α-发射体 224 Ra后患白血病和其他恶性疾病

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We performed an epidemiological study on 1,471 ankylosing spondylitis patients treated with repeated intravenous injections of the short lived α-emitter 224Ra (excluding radiation therapy with X-rays) between 1948 and 1975. These patients have been followed together with a control group of 1,324 ankylosing spondylitis patients treated neither with radioactive drugs nor with X-rays. The mean follow-up time was 26.3 years in the exposed and 24.6 years in the control group. To date, causes of death have been ascertained for 1,006 exposed patients and 1,072 controls. Special emphasis was placed on the reporting of malignant diseases. Expected numbers of cases were computed for the age, sex and calendar year distribution of both groups using cancer registry incidence rates. In the exposed group 18 cases of kidney cancer (vs. 9.1 cases expected, P < 0.01) and 4 malignant thyroid tumours (vs. 1.2 cases expected, P = 0.03) were observed. In the control group the observed cases for these tumours were not significantly elevated. The most striking observation, however, were the 21 cases of leukaemia in the exposed group (vs. 6.8 cases expected, P < 0.001) compared to 12 cases of leukaemia in the control group (vs. 7.5 cases expected). Further sub-classification of the leukaemias demonstrated a high increase of myeloid leukaemia in the exposed group (12 cases observed vs. 2.9 cases expected, P < 0.001), and out of these, especially a high excess of acute myeloid leukaemias (7 cases observed vs. 1.8 expected, P = 0.003). In the controls the observed cases are within the expected range (4 myeloid leukaemias vs. 3.1 cases). This increase in total leukaemias as well as particularly in myeloid leukaemias is significant in direct comparison between the exposed and control groups too (P < 0.05). The enhanced leukaemia incidence in the exposed group is in line with the observation of increased leukaemia incidence in mice injected with 224Ra.
机译：在1948年至1975年之间，我们对1471例强直性脊柱炎患者进行了流行病学研究，这些患者经反复静脉注射短命α-发射体 224 Ra（不包括X射线放射治疗）进行治疗。与对照组的1,324名强直性脊柱炎患者既未接受放射性药物治疗也未接受X射线治疗。暴露组的平均随访时间为26.3年，对照组为24.6年。迄今为止，已经确定了1,006名暴露患者和1,072名对照的死亡原因。特别强调了恶性疾病的报告。使用癌症登记册发病率，计算两组的年龄，性别和日历年分布的预期病例数。在暴露组中，观察到18例肾癌（预期9.1例，P <0.01）和4例甲状腺恶性肿瘤（预期1.2例，P = 0.03）。在对照组中，观察到的这些肿瘤的病例没有显着升高。然而，最引人注目的观察结果是暴露组的21例白血病（预期为6.8例，P <0.001），而对照组的12例白血病（预期为7.5例）。白血病的进一步亚分类显示，暴露人群中髓样白血病的高度增加（观察到12例，预期为2.9例，P <0.001），其中尤其是急性髓样白血病过多（观察到7例）相对于预期的1.8，P = 0.003）。在对照组中，观察到的病例在预期范围内（4例髓性白血病vs. 3.1例）。总白血病的增加，尤其是髓样白血病的增加，在暴露组和对照组之间的直接比较中也很显着（P <0.05）。暴露组中白血病发生率的增加与 224 Ra注射的小鼠中白血病发生率的增加相一致。

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