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首页> 外文期刊>Radiation Protection Dosimetry >ACUTE MYELOID LEUKEMIA, PROSTATE AND SKIN CANCER IN ACUTE RADIATION SYNDROME SURVIVOR AFTER THE 1986 CHERNOBYL NUCLEAR ACCIDENT: CASE REPORT
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ACUTE MYELOID LEUKEMIA, PROSTATE AND SKIN CANCER IN ACUTE RADIATION SYNDROME SURVIVOR AFTER THE 1986 CHERNOBYL NUCLEAR ACCIDENT: CASE REPORT

机译：1986年切尔诺贝利核事故后急性放射综合征患者的急性髓细胞白血病，前列腺癌和皮肤癌：病例报告

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摘要

The development of hemoblastosis is often associated with the influence of various genotoxic unfavorable factors, in particular, with the effect of ionizing radiation. This article presents a case report of acute myeloid leukemia (AML) in a patient who was involved in the 1986 accident at the Chernobyl Nuclear Power Plant and suffered an acute radiation syndrome of degree II severity. Based on clinical and cytogenetic dosimetry, the average absorbed radiation dose to the whole body was estimated to be 4.3 Gy. During long-term clinical follow-up (27 years), moderate transient instability of hematological parameters was observed: lymphocytosis, leukopenia and thrombocytopenia, which was associated with chronic viral hepatitis C. Further cytogenetic investigations demonstrated a very high frequency of translocations, up to 50 times background values, that persisted over 3 decades. In 2014, the patient was diagnosed and operated on for prostate cancer and received a course of radiotherapy (total fractionated local dose of 35 Gy) in May 2015. From December 2015 through April 2016, the patient experienced general weakness and developed progressive cytopenia. A diagnosis of AML, resulting from a myelodysplastic syndrome, was confirmed by abnormal complex clones detected in 38% of metaphases by the mFISH-method, along with other chromosomal rearrangements. The patient underwent several chemotherapy treatments for AML but eventually died of bilateral pneumonia in March 2017.
机译：血红细胞增多症的发展通常与各种遗传毒性不利因素的影响有关，特别是与电离辐射的影响有关。本文介绍了一名患者的急​​性髓细胞性白血病（AML）的病例报告，该患者参与了1986年切尔诺贝利核电站事故，并患有II级严重的急性放射综合症。根据临床和细胞遗传学剂量学，估计对全身的平均吸收辐射剂量为4.3 Gy。在长期的临床随访（27年）中，观察到血液学参数的中度暂时性不稳定：淋巴细胞增多，白细胞减少和血小板减少，与慢性丙型肝炎病毒有关。进一步的细胞遗传学研究表明，易位率很高，直至是背景值的50倍，持续了3年。 2014年，该患者被诊断并接受了前列腺癌手术，并于2015年5月接受了放射治疗（局部总局部剂量为35 Gy）。从2015年12月至2016年4月，患者经历了全身无力并发展为进行性血细胞减少症。通过mFISH方法在38％的中期检测到异常复杂的克隆以及其他染色体重排，证实了由骨髓增生异常综合症引起的AML诊断。该患者接受了AML的几种化学疗法治疗，但最终于2017年3月因双侧肺炎死亡。

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