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首页> 外文期刊>Radiation Protection Dosimetry >AN EMERGENCY RADIOBIOASSAY METHOD FOR ~(226)Ra IN HUMAN URINE SAMPLES
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AN EMERGENCY RADIOBIOASSAY METHOD FOR ~(226)Ra IN HUMAN URINE SAMPLES

机译：尿液样品中〜（226）Ra的紧急放射线放射分析方法

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摘要

A new radioanalytical method was developed for rapid determination of ~(226)Ra in human urine samples. The method is based on organic removal and decolonisation of a urine sample by a polymeric (acrylic ester) solid phase sorbent material followed by extraction and preconcentration of ~(226)Ra in an organic solvent using a dispersive liquid-liquid microextraction technique. Radiometric measurement of ~(226)Ra was carried out using a liquid scintillation counting instrument. The minimum detectable activity for the method (0.15 Bq l~(-1)) is lower than the required sensitivity of 0.2 Bq I for ~(226)Ra in human urine samples as defined in the requirements for radiation emergency bioassay techniques for the public and first responders based on the dose threshold for possible medical attention recommended by the International Commission on Radiological Protection (ICRP). The accuracy (expressed as relative bias, B_t) and repeatability of the method (expressed as relative precision, S_B) evaluated at the reference level (2 Bq 1~(-1)) were found to be -4.5 and 2.6 %, respectively. The sample turnaround time was <5 h for a single urine sample and <20 h for a batch of six urine samples. With the fast sample turnaround time combined with the potential to carry out the analysis in a field deployable mobile laboratory, the newly developed method can be used for emergency radiobioassay of ~(226)Ra in human urine samples following a radiological or nuclear accident.
机译：开发了一种新的放射分析方法，用于快速测定人尿液样品中的〜（226）Ra。该方法的基础是：通过聚合（丙烯酸酯）固相吸附剂对尿液样本进行有机去除和非殖民化，然后使用分散液-液微萃取技术在有机溶剂中萃取和预浓缩〜（226）Ra。使用液体闪烁计数仪进行〜（226）Ra的辐射测定。该方法的最低可检测活性（0.15 Bq l〜（-1））低于对人体尿液样品中〜（226）Ra的0.2 Bq I灵敏度的要求，这在公众放射应急生物测定技术的要求中已定义以及基于国际放射防护委员会（ICRP）建议的可能就医的剂量阈值的第一响应者。在参考水平（2 Bq 1〜（-1））处评估的方法的准确性（表示为相对偏差B_t）和可重复性（表示为相对精度S_B）分别为-4.5和2.6％。对于单个尿液样品，样品周转时间为<5小时，对于六个尿液样品，样品周转时间为<20小时。凭借快速的样品周转时间以及在现场可部署的移动实验室中进行分析的潜力，这种新开发的方法可用于放射性或核事故后人类尿液样品中〜（226）Ra的紧急放射生物测定。

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  • 来源
    《Radiation Protection Dosimetry》 |2012年第1期|p.10-16|共7页
  • 作者

    Baki B. Sadi; Chunsheng Li; Gary H. Kramer;

  • 作者单位

    National Internal Radiation Assessment Section, Radiation Protection Bureau, Health Canada, 775 Brookfield Road, A.L. 6302D, Ottawa, ON, Canada K1A 1C1;

    National Internal Radiation Assessment Section, Radiation Protection Bureau, Health Canada, 775 Brookfield Road, A.L. 6302D, Ottawa, ON, Canada K1A 1C1;

    National Internal Radiation Assessment Section, Radiation Protection Bureau, Health Canada, 775 Brookfield Road, A.L. 6302D, Ottawa, ON, Canada K1A 1C1;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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