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首页> 外文期刊>Radiation Protection Dosimetry >A REVISION OF THE ORGAN RADIATION DOSES FROM 2-FLUORO-2-DEOXY-D-GLUCOSE WITH REFERENCE TO TUMOUR PRESENCE
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A REVISION OF THE ORGAN RADIATION DOSES FROM 2-FLUORO-2-DEOXY-D-GLUCOSE WITH REFERENCE TO TUMOUR PRESENCE

机译：关于2-氟-2-脱氧-D-葡萄糖的有机辐射剂量的修订

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摘要

Absorbed radiation doses to major human organs after intravenous bolus administration of 2-[~(18)F]fluoro-2-deoxy-D-glucose (FDG) were reviewed. Absorbed doses were calculated using the medical internal radiation dose (MIRD) formalism from experimental activity-time curves. Thirty patients (22 with macroscopic lung tumour and 8 without observable disease) were investigated using a state-of-the-art combined positron emission tomography /computer tomography system (Siemens Biograph 64). Each patient underwent a series of 10 consecutive whole-body PET scans during the first 60-min post-FDG administration. Differences were observed between organ radiation doses in this work and those reported in International Commission for Radiation Protection 106 (21 % in effective dose). The presence of tumour did not affect the FDG biodistribution. Large inter-individual variations in organ-absorbed doses were observed. This in combination with the lack of a model for bladder voiding suitable for all patients suggests the need for a more precise estimate of normal-organ radiation doses. This will be beneficial in optimising FDG administration in clinical routine.
机译：回顾了静脉推注2- [〜（18）F]氟-2-脱氧-D-葡萄糖（FDG）后人体主要器官的吸收辐射剂量。根据实验活动时间曲线，使用医学内部辐射剂量（MIRD）形式来计算吸收剂量。使用最新的正电子发射断层扫描/计算机断层扫描系统（Siemens Biograph 64）对30例患者（22例患有宏观肺肿瘤，8例未观察到疾病）进行了研究。在FDG给药后的最初60分钟内，每位患者进行了10次连续的全身PET扫描。在这项工作中观察到器官辐射剂量与国际辐射防护委员会106报告的剂量之间存在差异（有效剂量为21％）。肿瘤的存在并不影响FDG的生物分布。观察到个体间器官吸收剂量存在较大的个体差异。再加上缺乏适用于所有患者的膀胱排尿模型，这表明需要更精确地估算正常器官放射剂量。这将有助于优化临床常规中的FDG给药。

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  • 来源
    《Radiation Protection Dosimetry》 |2012年第1期|p.43-50|共8页
  • 作者

    Johan Staaf; Hans Jacobsson; Alejandro Sanchez-Crespo;

  • 作者单位

    Department of Physics, Stockholm University, Stockholm, Sweden,Department of Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden;

    Department of Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden,Department of Radiology, Karolinska University Hospital, Stockholm, Sweden;

    Department of Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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