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Age-dependent Potassium Iodide Effect On The Thyroid Irradiation By ~(131)i And ~(133)i In The Nuclear Emergency

机译:年龄相关的碘化钾对核事故中〜(131)i和〜(133)i甲状腺照射的影响

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摘要

The initial near-field exposure is primarily through inhalation in a nuclear emergency and the dominant contribution to the effective inhalation dose comes from radioiodine. Thyroid blockade by oral potassium iodide (KI) is efficient and practical for public in the nuclear emergency. Age-dependent radioprotective effect of KI on the thyroid irradiation by ~(131)I and ~(133)I has been derived using the simplified compartment model of iodine metabolism and WinSAAM program. Administration of KI within 2 h after ~(131)I and ~(133)I intake can block thyroid uptake significantly, yielding protective effect of 78.9% and 74.3%, respectively, for~(131)I and~(133)I for adults. The mean absorbed doses decrease with age, while protective effects of KI are similar for all age groups.
机译:最初的近场暴露主要是通过核紧急情况下的吸入,而对有效吸入剂量的主要贡献来自放射性碘。口服碘化钾(KI)对甲状腺的阻滞对于核事故中的公众是有效和实用的。使用碘代谢的简化区室模型和WinSAAM程序,得出了KI对〜(131)I和〜(133)I对甲状腺辐射的年龄依赖性辐射防护作用。摄入〜(131)I和〜(133)I后2小时内施用KI可以显着阻断甲状腺摄取,对〜(131)I和〜(133)I的保护作用分别为78.9%和74.3%。大人。平均吸收剂量随年龄而降低,而KI对所有年龄组的保护作用均相似。

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