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THE ROLE OF STRESS RESPONSES IN DETERMINING CELL FATE FOLLOWING EXPOSURE TO ULTRA VIOLET RADIATION

机译:紫外线照射后应激反应在确定细胞命运中的作用

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摘要

Cellular stress responses are believed to play an important role in promoting the survival of mammalian cells under adverse conditions, such as exposure to ultraviolet radiation (UVR). Membrane-associated tyrosine kinase activity constitutes an important element of the UV response of HeLa and other non-skin cells. Using a panel of protein kinase inhibitors it was confirmed that tyrosine kinase activation promotes the survival of UV-irradiated HeLa S3 cells, an effect that appeared to be either predominantly or wholly due to an inhibition of epidermal growth factor receptor.
机译:据信细胞应激反应在促进哺乳动物细胞在不利条件下(例如暴露于紫外线辐射(UVR))下的存活中起重要作用。膜相关的酪氨酸激酶活性是HeLa和其他非皮肤细胞紫外线反应的重要组成部分。使用一组蛋白激酶抑制剂,已证实酪氨酸激酶激活促进了紫外线照射的HeLa S3细胞的存活,这种作用似乎主要或完全是由于对表皮生长因子受体的抑制。

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