CHARACTERISATION OF HUMAN KERATIONCYTES BY MEASURING CELLULAR REPAIR CAPACITY OF UVB- INDUCED DNA DAMAGE AND MONITORING OF CYTOGENETIC CHANGES IN MELANOMA CELL LINES

R. Greinert; E. W. Breitbart; D. Mitchell

首页> 外文期刊>Radiation Protection Dosimetry >CHARACTERISATION OF HUMAN KERATIONCYTES BY MEASURING CELLULAR REPAIR CAPACITY OF UVB- INDUCED DNA DAMAGE AND MONITORING OF CYTOGENETIC CHANGES IN MELANOMA CELL LINES

【24h】

CHARACTERISATION OF HUMAN KERATIONCYTES BY MEASURING CELLULAR REPAIR CAPACITY OF UVB- INDUCED DNA DAMAGE AND MONITORING OF CYTOGENETIC CHANGES IN MELANOMA CELL LINES

机译：通过测量紫外线诱导的DNA损伤的细胞修复能力并监测黑素瘤细胞系中细胞遗传学变化来表征人类角质形成细胞

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The molecular mechanisms for UV-induced photocarcinogenesis are far from being understood in detail, especially in the case of malignant melanoma of the skin. Nevertheless, it is known that deficiencies in cellular repair processes of UV- induced DNA damage (e. g. in the case of Xeroderma pigmentosum) represent important aetiological factors in the multistep- development of skin cancer. The repair kinetics have therefore been studied of an established skin cell line (HaCaT), primary human keratinocytes, melanocytes and melanoma cell lines, using fluorescence microscopy and flow cytometry.

机译：紫外线引起的光致癌作用的分子机制尚不清楚，特别是在皮肤恶性黑色素瘤的情况下。然而，已知的是，紫外线诱导的DNA损伤的细胞修复过程中的缺陷（例如在色皮干燥杆菌的情况下）在皮肤癌的多步发展中代表重要的病因。因此，已经使用荧光显微镜和流式细胞术研究了已建立的皮肤细胞系（HaCaT），原代人角质形成细胞，黑素细胞和黑色素瘤细胞系的修复动力学。

著录项

来源
《Radiation Protection Dosimetry》 |2000年第3期|p.41-45|共5页
作者
R. Greinert; E. W. Breitbart; D. Mitchell;
展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类 TL72;
关键词

相似文献

外文文献
中文文献
专利

1. Investigating the role of melanin in UVA/UVB- and hydrogen peroxide-induced cellular and mitochondrial ROS production and mitochondrial DNA damage in human melanoma cells [J] . SwalwellH., LatimerJ., HaywoodR.M., Free Radical Biology and Medicine: The Official Journal of the Oxygen Society . 2012,第3期

机译：研究黑色素在人黑色素瘤细胞中UVA / UVB和过氧化氢诱导的细胞和线粒体ROS产生以及线粒体DNA损伤中的作用
2. Triptolide induced DNA damage in A375.S2 human malignant melanoma cells is mediated via reduction of DNA repair genes [J] . ChuehF.-S., ChenY.-L., HsuS.-C., Oncology reports . 2013,第2期

机译：雷公藤甲素诱导的A375.S2人恶性黑色素瘤细胞DNA损伤是通过减少DNA修复基因来介导的
3. Taxing the cellular capacity for repair: human T-cell leukemia virus type 1, DNA damage, and adult T-cell leukemia (editorial; comment) [J] . Kibler KV, Jeang KT Journal of the National Cancer Institute . 1999,第11期

机译：增加细胞修复能力的负担：1型人类T细胞白血病病毒，DNA损伤和成人T细胞白血病（编辑;评论）
4. Evaluation of DNA damage induced by proton and lithium beams in murine melanoma cells [C] . IL Iba?ez, C Bracalente, M Edreira, Congress of the International Radiation Protection Association;IRPA 12 . 2010

机译：质子和锂束对小鼠黑色素瘤细胞DNA损伤的评估
5. Characterisation of DNA damage inducible responses and repair in human cells using recombinant adenovirus vectors. [D] . Francis, Murray Albert. 2000

机译：使用重组腺病毒载体表征人细胞中的DNA损伤诱导反应和修复。
6. Monitoring Repair of DNA Damage in Cell Lines and Human Peripheral Blood Mononuclear Cells [O] . Hyun-Wook Lee, Hae-Jung Lee, Chong-mu Hong, -1

机译：监测细胞系和人外周血单个核细胞中DNA损伤的修复
7. Retraction: Cadmium Induced Cell Apoptosis, DNA Damage, Decreased DNA Repair Capacity, and Genomic Instability during Malignant Transformation of Human Bronchial Epithelial Cells [O] . Zhiheng Zhou, Caixia Wang, Haibai Liu, 2014

机译：收缩：镉诱导细胞凋亡，DNA损伤，DNA修复能力下降，和人支气管上皮细胞恶性转化期间的基因组不稳定性

CHARACTERISATION OF HUMAN KERATIONCYTES BY MEASURING CELLULAR REPAIR CAPACITY OF UVB- INDUCED DNA DAMAGE AND MONITORING OF CYTOGENETIC CHANGES IN MELANOMA CELL LINES

摘要

著录项

相似文献

相关主题

期刊订阅