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首页> 外文期刊>Receptors and Channels >Human Gastric Tissues Simultaneously Express the Classical and Alternative Splicing Cholecystokinin-B/Gastrin Receptors
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Human Gastric Tissues Simultaneously Express the Classical and Alternative Splicing Cholecystokinin-B/Gastrin Receptors

机译：人体胃组织同时表达经典和替代剪接的胆囊收缩素-B /胃泌素受体

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摘要

To explore whether cholecystokinin-B/gastrin receptor (CCKBRwt) gene and its alternative splicing variant preserving intron 4 (CCKBRi4sv) are expressed in human gastric carcinoma cell line and tissue, we detect mRN A expression of CCKBRwt and CCKBRi4sv in 30 gastric carcinoma and their corresponding normal tissues, 10 gastritis, and 2 autopsied normal stomach specimens as well as in a gastric carcinoma cell line SGC-7901 cells by RT-PCR and sequencing. The results revealed that human normal, inflammatory, and malignant gastric tissues simultaneously expressed the classical and alternative splicing cholecystokinin-B/gastrin receptor genes. The alternative splicing variant contains the intron 4 of cholecystokinin-B/gastrin receptor gene.
机译：为了探讨胆囊收缩素-B /胃泌素受体基因（CCKBRwt）及其替代剪接变体内含子4（CCKBRi4sv）在人胃癌细胞系和组织中的表达，我们检测了30例胃癌及其癌中CCKBRwt和CCKBRi4sv的mRNA表达。相应的正常组织，10个胃炎和2个尸体解剖正常胃标本以及胃癌细胞系SGC-7901细胞中的RT-PCR和测序结果。结果表明，人的正常，炎症和恶性胃组织同时表达了经典的和另类的拼接胆囊收缩素-B /胃泌素受体基因。可选的剪接变体包含胆囊收缩素-B /胃泌素受体基因的内含子4。

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