Mechanism of action of 1,25-dihydroxyvitamin D<sub>3</sub> on intestinal calcium absorption

Sylvia Christakos

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Mechanism of action of 1,25-dihydroxyvitamin D₃ on intestinal calcium absorption

机译：1,25-二羟基维生素D _{3 对肠道钙吸收的作用机理}

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1,25-Dihydroxyvitamin D₃ (1,25(OH)₂D₃) is the major controlling hormone of intestinal calcium absorption. As the body’s demand for calcium increases from a diet deficient in calcium, from growth, pregnancy or lactation, the synthesis of 1,25(OH)₂D₃ is increased resulting in the stimulation of intestinal calcium absorption. However a complete description of the molecular mechanisms involved in the 1,25(OH)₂D₃ regulated calcium absorptive process remains incomplete. Intestinal calcium absorption occurs by both an active saturable transcellular pathway and a passive nonsaturable paracellular pathway. Each step in the process of transcellular calcium transport (apical entry of calcium, translocation of calcium through the interior of the enterocyte and basolateral extrusion of calcium by the plasma membrane pump) has been reported to involve a vitamin D dependent component. This article will review recent studies, including those using knockout mice, that have suggested that 1,25(OH)₂D₃ mediated calcium absorption is more complex than the traditional three step model of transcellular calcium transport. Current concepts are reviewed and questions that remain are addressed. Evidence for a role of 1,25(OH)₂D₃ in the regulation of the paracellular pathway is also discussed.

机译：1,25-二羟基维生素D _{3 （1,25（OH）_{2 D _{3 ）是肠道钙吸收的主要控制激素。由于缺乏钙的饮食，生长，怀孕或哺乳期人体对钙的需求增加，因此1,25（OH）_{2 D _{3 的合成增加在刺激肠道钙的吸收。然而，有关1,25（OH）_{2 D _{3 调节钙吸收过程的分子机制的完整描述仍然不完整。肠道钙吸收通过主动的饱和跨细胞途径和被动的非饱和旁细胞途径发生。据报道，跨细胞钙转运过程中的每个步骤（钙的顶端进入，钙通过肠上皮细胞内部的转运以及质膜泵对钙的基底外侧挤压）都涉及维生素D依赖性成分。本文将回顾最近的研究，包括使用敲除小鼠的研究，这些研究表明1,25（OH）_{2 D _{3 介导的钙吸收比传统的3种更为复杂。跨细胞钙转运的模型。审查当前的概念，并解决剩余的问题。还讨论了1,25（OH）_{2 D _{3 在旁细胞途径调控中的作用的证据。}}}}}}}}}}}

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《Reviews in Endocrine & Metabolic Disorders》 |2012年第1期|p.39-44|共6页
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Sylvia Christakos;
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1. Mechanism of action of 1,25-dihydroxyvitamin D 3 on intestinal calcium absorption [J] . ChristakosS. Reviews in endocrine & metabolic disorders . 2012,第1期

机译：1,25-二羟基维生素D 3对肠道钙吸收的作用机理
2. Contribution of intestinal calcium absorption to 1,25-dihydroxyvitamin D3-induced calcium action in the total parenteral nutrition rat. [J] . Asanuma K, Komatsu S, Sakurai T, The Journal of toxicological sciences . 2006,第4期

机译：总肠胃外营养大鼠肠道钙吸收对1,25-二羟基维生素D3诱导的钙作用的贡献。
3. Differential effects of 19-nor-1,25-dihydroxyvitamin D(2) and 1,25-dihydroxyvitamin D(3) on intestinal calcium and phosphate transport. [J] . Brown AJ, Finch J, Slatopolsky E The Journal of laboratory and clinical medicine . 2002,第5期

机译：19-nor-1,25-dihydroxyvitamin D（2）和1,25-dihydroxyvitamin D（3）对肠钙和磷酸盐转运的差异作用。
4. Effect of dietary calcium: Phosphorus ratio on bone mineralization and intestinal calcium absorption in ovariectomized rats [C] . Moyuru Koshihara, Ritsuko Masuyama, Mariko Uehara, International Conference on Food Factors . 2004

机译：膳食钙的影响：卵巢骨化磷比对卵巢切除大鼠的含量和肠钙吸收
5. Role of protein kinase c isotypes in 1,25 dihydroxyvitamin D3 mediated signal transduction through the 1,25-D3 membrane associated, rapid response steroid binding receptors in chick intestinal cells [D] . Tunsophon, Sakara 2010

机译：蛋白激酶c同种型在鸡肠道细胞中通过1,25-D3膜相关的快速响应类固醇结合受体在1,25-二羟基维生素D3介导的信号转导中的作用
6. The role of 1 alpha 25-dihydroxyvitamin D in the mediation of intestinal hyperabsorption of calcium in primary hyperparathyroidism and absorptive hypercalciuria. [O] . R A Kaplan, M R Haussler, L J Deftos, 1977

机译：1α25-二羟基维生素D在原发性甲状旁腺功能亢进症和吸收性高钙尿症中对钙的肠道高吸收的介导中的作用。
7. Relationship of Intestinal Calcium Absorption to 1,25-Dihydroxyvitamin D 1,25(OH)2D Levels in YoungVersusElderly Women: Evidence for Age-Related Intestinal Resistance to 1,25(OH)2D Action1 [O] . S. Pattanaungkul, B. L. Riggs, A. L. Yergey, 2000

机译：肠道钙吸收与1,25-二羟基苯胺D的关系1,25（OH）2D水平，妇女：年龄相关的肠道抵抗症的证据于1,25（OH）2D Action1
8. Calcium Accumulation by Chick Intestinal Mitochondria Regulation by Vitamin D-3 and 1,25-Dihydroxyvitamin D-3 [R] . Bikle, D. D., Askew, E. W., Zolock, D. T., 1979

机译：维生素D-3和1,25-二羟维生素D-3调节鸡肠线粒体钙的积累

Mechanism of action of 1,25-dihydroxyvitamin D3 on intestinal calcium absorption

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Mechanism of action of 1,25-dihydroxyvitamin D₃ on intestinal calcium absorption