Pancreatic β-cell K<sub>ATP</sub> channels: Hypoglycaemia and hyperglycaemia

Kate Bennett; Chela James; Khalid Hussain

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Pancreatic β-cell K_ATP channels: Hypoglycaemia and hyperglycaemia

机译：胰β细胞K _{ATP 通道：低血糖和高血糖}

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The pancreatic β-cell ATP-sensitive K+ channel (K_ATP channel) plays a critical role in glucose homeostasis by linking glucose metabolism to electrical excitability and insulin secretion. Changes in the intracellular ratio of ATP/ADP mediate the metabolic regulation of channel activity. The β-cell K_ATP channel is a hetero-octameric complex composed of two types of subunits: four inward-rectifying potassium channel pore-forming (Kir6.2) subunits and four high-affinity sulfonylurea receptor 1 (SUR1) subunits. Kir6.2 and SUR1 are encoded by the genes KCNJ11 and ABCC8, respectively. Mutations in these genes can result in congenital hyperinsulinism and permanent neonatal diabetes. This review highlights the important role of the β-cell K_ATP channel in glucose physiology and provides an introduction to some of the other review articles in this special edition of the Reviews in Endocrine and Metabolic Disorders.

机译：胰岛β细胞ATP敏感的K + 通道（K _{ATP 通道）通过将葡萄糖代谢与电兴奋性和胰岛素分泌联系起来，在葡萄糖稳态中发挥关键作用。 ATP / ADP的细胞内比率的变化介导了通道活性的代谢调节。 β细胞K _{ATP 通道是由两种亚基组成的杂八聚体复合物：四个内向整流钾通道成孔（Kir6.2）亚基和四个高亲和力磺酰脲受体1 （SUR1）亚单位。 Kir6.2和SUR1分别由基因KCNJ11和ABCC8编码。这些基因的突变可导致先天性高胰岛素血症和永久性新生儿糖尿病。这篇综述强调了β细胞K _{ATP 通道在葡萄糖生理学中的重要作用，并介绍了本期《内分泌和代谢紊乱评论》特刊中的其他一些评论文章。}}}

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《Reviews in Endocrine & Metabolic Disorders》 |2010年第3期|p.157-163|共7页
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Kate Bennett; Chela James; Khalid Hussain;
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1. Pancreatic beta-cell KATP channels: Hypoglycaemia and hyperglycaemia. [J] . Bennett K, James C, Hussain K Reviews in endocrine & metabolic disorders . 2010,第3期

机译：胰腺β细胞KATP通道：低血糖和高血糖。
2. Iptakalim,a Vascular ATP-Sensitive Potassium(K_(ATP))Channel Opener,Closes Rat Pancreatic beta-Cell K_(ATP)Channels and Increases Insulin Release [J] . Naoko Misaki, Xia Mao, Yu-Fung Lin The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2007,第2期

机译：依帕卡林，一种血管ATP敏感性钾（K_（ATP））通道开放剂，关闭大鼠胰腺β细胞K_（ATP）通道并增加胰岛素释放
3. Morphological changes in pancreatic islets of KATP channel-deficient mice: the involvement of KATP channels in the survival of insulin cells and the maintenance of islet architecture. [J] . Winarto A, Miki T, Seino S, Archives of histology and cytology. . 2001,第1期

机译：KATP通道缺陷小鼠的胰岛的形态变化：KATP通道参与胰岛素细胞的存活和胰岛结构的维持。
4. ATP-SENSITIVE K CHANNEL IS NOT INVOLVED IN THEEXTRACELLULAR K ACCUMULATION IN ISCHEMICMOUSE HEART [C] . TOSHIAKI SATO, TOMOAKI SAITO, TAKASHIMIKI, International Congress on Electrocardiology . 2005

机译：ATP敏感k频道不涉及缺血性心脏中的Xtracellular K积累
5. The L-type voltage-gated calcium channels: The role of Cav1.2 in pancreatic B cells and new perspective on the molecular pharmacology of Cav1.3. [D] . Wang, Yuchen. 2015

机译：L型电压门控钙通道：Cav1.2在胰腺B细胞中的作用以及Cav1.3分子药理学的新观点。
6. ATP-sensitive K+ channels in rat pancreatic beta-cells: modulation by ATP and Mg2+ ions. [O] . F M Ashcroft, M Kakei 1989

机译：大鼠胰腺β细胞中的ATP敏感K +通道：由ATP和Mg2 +离子调节。
7. Expression of ATP-Insensitive KATP Channels in Pancreatic -Cells Underlies a Spectrum of Diabetic Phenotypes [O] . J. C. Koster, M. S. Remedi, R. Masia, 2006

机译：在胰腺 - 细胞中的ATP不敏感KATP通道的表达是糖尿病表型的光谱

Pancreatic β-cell KATP channels: Hypoglycaemia and hyperglycaemia

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Pancreatic β-cell K_ATP channels: Hypoglycaemia and hyperglycaemia