• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Reviews on environmental health >Long-term health consequences of prenatal arsenic exposure: links to the genome and the epigenome
【24h】

Long-term health consequences of prenatal arsenic exposure: links to the genome and the epigenome

机译：产前砷暴露的长期健康后果：与基因组和表观基因组的联系

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Arsenic continues to poison the water of millions of individuals around the globe. Despite the potentially devastating effects of arsenic on worldwide human health, the impacts of such exposure on vulnerable populations including pregnant women and their unborn children are understudied. Data from human populations exposed early in life highlight the increased mortality risks related to both cancer and non-cancer endpoints. The molecular underpinnings for these effects are largely unknown. Here we highlight the current studies linking prenatal arsenic exposure and health effects, particularly those that examined associations between arsenic exposure and altered genomic and epigenetic signaling. Current needs in the field to increase our understanding of the molecular basis for adult disease are mentioned.
机译：砷继续毒害全球数百万人的水。尽管砷可能对全世界的人类健康造成毁灭性的影响，但人们仍未充分研究砷暴露对包括孕妇及其未出生婴儿在内的脆弱人群的影响。来自生命早期暴露人群的数据突显了与癌症和非癌症终点相关的死亡风险增加。这些作用的分子基础在很大程度上是未知的。在这里，我们重点介绍了将产前砷暴露与健康影响联系起来的最新研究，尤其是那些研究了砷暴露与基因组和表观遗传信号改变之间关系的研究。提到了该领域当前对增进我们对成人疾病的分子基础的理解的需求。

著录项

  • 来源
    《Reviews on environmental health》 |2014年第2期|9-12|共4页
  • 作者

    Kathryn Bailey; Rebecca C. Fry;

  • 作者单位

    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA;

    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, 135 Dauer Drive, CB 7431, Chapel Hill, NC 27599, USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    arsenic; epigenome; genome; prenatal exposure;

    机译：砷;表观基因组基因组产前暴露;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号